• Miscellaneous hematological agents

Adakveo Generic Name & Formulations

General Description

Crizanlizumab-tmca 10mg/mL; per vial; soln for IV infusion after dilution; preservative-free.

Pharmacological Class

Selectin blocker.

How Supplied

Single-dose vial (10mL)—1

Generic Availability


Adakveo Indications


To reduce the frequency of vaso-occlusive crises (VOCs) in sickle cell disease.

Adakveo Dosage and Administration


Give by IV infusion over 30mins. ≥16yrs: 5mg/kg at Week 0, Week 2, and every 4 weeks thereafter.


<16yrs: not established.

Adakveo Contraindications

Not Applicable

Adakveo Boxed Warnings

Not Applicable

Adakveo Warnings/Precautions


Monitor for infusion-related reactions. Discontinue if severe infusion-related reactions occur; treat appropriately. Interrupt or slow infusion rate if mild to moderate infusion-related reactions occur; treat symptomatically. Consider premedication and/or reduced infusion rate for subsequent infusions. Pregnancy. Nursing mothers.

Adakveo Pharmacokinetics

See Literature

Adakveo Interactions


Caution with corticosteroids, unless indicated (eg, treating anaphylaxis). Interferes with automated platelet counts (esp. when collected in tubes containing EDTA) that may lead to unevaluable or falsely decreased platelet counts; run tests within 4hrs of collection or collect in citrate tubes instead.

Adakveo Adverse Reactions

Adverse Reactions

Nausea, arthralgia, back pain, abdominal pain, pyrexia; infusion-related reactions.

Adakveo Clinical Trials

See Literature

Adakveo Note

Not Applicable

Adakveo Patient Counseling

See Literature