Miscellaneous hematological agents:

Indications for ADAKVEO:

To reduce the frequency of vaso-occlusive crises (VOCs) in sickle cell disease.

Adult:

Give by IV infusion over 30mins. ≥16yrs: 5mg/kg at Week 0, Week 2, and every 4 weeks thereafter.

Children:

<16yrs: not established.

Warnings/Precautions:

Monitor for infusion-related reactions; discontinue and treat if severe. Pregnancy. Nursing mothers.

Pharmacologic Class:

Selectin blocker.

Interactions:

Interferes with automated platelet counts (esp. when collected in tubes containing EDTA) that may lead to unevaluable or falsely decreased platelet counts; run tests within 4hrs of collection or collect in citrate tubes instead.

Adverse Reactions:

Nausea, arthralgia, back pain, pyrexia; infusion-related reactions.

Generic Availability:

NO

How Supplied:

Single-dose vial (10mL)—1

Pricing for ADAKVEO

10ml of 10mg/ml vial (Qty: 1)
Appx. price $2414
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