• Viral infections

Acyclovir Generic Name & Formulations

General Description

Acyclovir 200mg; caps.

Pharmacological Class

Nucleoside analogue.

How Supplied

Caps, tabs—contact supplier; Susp—473mL

Acyclovir Indications


Genital herpes. Herpes zoster. Varicella.

Acyclovir Dosage and Administration


May give with food. Genital herpes: Initially 200mg every 4hrs (5 times daily) for 10 days. Chronic: 400mg 2 times daily or 200mg 3–5 times daily for up to 12 months, then reevaluate. Intermittent: (at 1st sign of recurrence) 200mg every 4hrs (5 times daily) for 5 days. Herpes zoster: 800mg every 4hrs (5 times daily) for 7–10 days. Varicella (start at earliest sign/symptom): 800mg 4 times daily for 5 days. Renal impairment: reduce dose (see full labeling); give another dose after hemodialysis.


<2yrs: not recommended. ≥2yrs: Varicella (start at earliest sign/symptom): 20mg/kg 4 times daily for 5 days; max 800mg/dose. >40kg: as adult. Others: see full labeling.

Acyclovir Contraindications


Valacyclovir hypersensitivity.

Acyclovir Boxed Warnings

Not Applicable

Acyclovir Warnings/Precautions


Renal impairment: see full labeling. Maintain adequate hydration. Pregnancy (Cat.B). Nursing mothers.

Acyclovir Pharmacokinetics

See Literature

Acyclovir Interactions


Avoid nephrotoxic drugs. Potentiated by probenecid.

Acyclovir Adverse Reactions

Adverse Reactions

Nausea, vomiting, headache, CNS disturbances (esp. elderly), diarrhea, vertigo, myalgia, rash, malaise, viral resistance, renal failure, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in immunocompromised patients.

Acyclovir Clinical Trials

See Literature

Acyclovir Note


Formerly known under the brand name Zovirax.

Acyclovir Patient Counseling

See Literature