• Diabetes

Actos Generic Name & Formulations

General Description

Pioglitazone (as HCl) 15mg, 30mg, 45mg; tabs.

Pharmacological Class


How Supplied

Tabs—30, 90, 500

Actos Indications


Adjunct to diet and exercise in type 2 diabetes, as monotherapy or in combination with metformin, insulin, or a sulfonylurea. Limitations of use: not for treating type 1 diabetes or diabetic ketoacidosis.

Actos Dosage and Administration


≥18yrs: Without CHF: initially 15mg or 30mg once daily; max 45mg once daily. With CHF (NYHA Class I or II): initially 15mg once daily. Concomitant insulin or sulfonylurea: reduce dose of these if needed. Concomitant strong CYP2C8 inhibitors: max 15mg daily.


<18yrs: not recommended.

Actos Contraindications


NYHA Class III or IV heart failure.

Actos Boxed Warnings

Boxed Warning

Congestive heart failure.

Actos Warnings/Precautions


Symptomatic HF: not recommended. Monitor for signs/symptoms of CHF; discontinue or reduce dose if occurs. Hepatic disease. Monitor liver function before initiating therapy; if abnormalities detected, interrupt and assess probable cause; do not restart if ALT >3XULN with total bilirubin >2XULN. Routine monitoring LFTs during therapy without liver disease: not recommended. Active bladder cancer: not recommended. Prior history of bladder cancer: consider glycemic control benefits vs. risk of cancer recurrence. Risk of fractures (esp. females). Perform regular eye exams. Resumption of premenopausal ovulation in anovulatory patients may occur (may result in unintended pregnancy). Pregnancy (Cat.C): consider using insulin instead. Nursing mothers: not recommended.

Actos Pharmacokinetics

See Literature

Actos Interactions


Potentiated by CYP2C8 inhibitors (eg, gemfibrozil). Antagonized by CYP2C8 inducers (eg, rifampin) or topiramate (monitor for adequate glycemic control). Antagonizes oral contraceptives, midazolam. Monitor for heart failure with insulin.

Actos Adverse Reactions

Adverse Reactions

Upper respiratory tract infection, headache, sinusitis, pharyngitis, myalgia, edema, weight gain, hypoglycemia, dyspnea; changes in serum lipids (may be beneficial), macular edema.

Actos Clinical Trials

See Literature

Actos Note

Not Applicable

Actos Patient Counseling

See Literature