• Bone disorders

Actonel Generic Name & Formulations

General Description

Risedronate (as sodium) 5mg, 30mg, 35mg, 75mg, 150mg; tabs.

Pharmacological Class


How Supplied

Tabs 5mg, 30mg—30; 35mg—4, 12; 75mg—2; 150mg—1, 3


Generic Availability


Actonel Indications


Prevention and treatment of postmenopausal osteoporosis and glucocorticoid-induced osteoporosis (men & women). Treatment to increase bone mass in men with osteoporosis. Treatment of Paget's disease of bone. Limitations of use: optimal duration of use has not been determined. For patients at low-risk for fracture, consider drug discontinuation after 3–5yrs.

Actonel Dosage and Administration


Swallow whole; take in the AM with a full glass (6–8oz) plain (not mineral) water at least 30min before other food or drink; take in upright position; do not lie down for at least 30min afterwards. Postmenopausal: 5mg once daily or 35mg once weekly or one 75mg tab taken on 2 consecutive days per month or one 150mg tab once monthly. Glucocorticoid-induced: 5mg once daily. Osteoporosis in men: 35mg once weekly. Paget's: 30mg once daily for 2 months; may retreat after a 2-month post-treatment evaluation period.


Not applicable.

Actonel Contraindications


Esophagus abnormalities which delay esophageal emptying (eg, stricture, achalasia). Inability to stand or sit upright for at least 30min. Hypocalcemia.

Actonel Boxed Warnings

Not Applicable

Actonel Warnings/Precautions


Active upper GI disease; discontinue and reevaluate if signs/symptoms of esophageal reaction occur. Severe renal impairment (CrCl <30mL/min): not recommended. Correct preexisting hypocalcemia, other mineral or bone disturbances before starting. Risk of osteonecrosis of the jaw; consider discontinuing therapy during invasive dental procedures (eg, tooth extraction, implants, surgery). History of bisphosphonate exposure: evaluate for atypical fractures if thigh/groin pain develops; consider withholding therapy until risk/benefit assessment. Obtain and correct sex steroid hormonal status before initiating therapy in glucocorticoid-induced osteoporosis. Ensure adequate Vit.D and calcium intake. Reevaluate periodically. Pregnancy: discontinue therapy when recognized. Nursing mothers.

Actonel Pharmacokinetics

See Literature

Actonel Interactions


Calcium, aluminum, magnesium, other divalent cations reduce absorption (separate dosing). Caution with other GI irritants. May interfere with bone-imaging agents.

Actonel Adverse Reactions

Adverse Reactions

Back pain, arthralgia, abdominal pain, dyspepsia, constipation, others; atypical femur fractures; rarely: dysphagia, esophagitis, gastric ulcer, jaw osteonecrosis, musculoskeletal pain (discontinue if severe); hypersensitivity.

Actonel Clinical Trials

See Literature

Actonel Note

Not Applicable

Actonel Patient Counseling

See Literature