• Miscellaneous diagnostic tests

Acthrel Generic Name & Formulations

General Description

Corticorelin ovine (as the trifluoroacetate) 100mcg/vial; pwd for IV inj after reconstitution.

Pharmacological Class

Corticotropin-releasing hormone (CRH) analogue.

How Supplied

Single-dose vial—1

Acthrel Indications


For use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushings syndrome.

Acthrel Dosage and Administration

Adults and Children

Testing pituitary corticotrophin function: 1mcg/kg IV as a single dose. ACTH and cortisol response prolonged and remain elevated for up to 2 hours. Doses >1mcg/kg: not recommended. If repeat test needed, do tests at the same time of day as original test.

Acthrel Contraindications

Not Applicable

Acthrel Boxed Warnings

Not Applicable

Acthrel Warnings/Precautions


Higher doses associated with transient tachycardia, decreased BP, loss of consciousness, and asystole; symptoms may be reduced if given as a 30 second IV infusion instead of bolus inj. Pregnancy (Cat.C). Nursing mothers.

Acthrel Pharmacokinetics

See Literature

Acthrel Interactions


Plasma ACTH response inhibited by dexamethasone. Heparin to maintain IV cannula patency: not recommended.

Acthrel Adverse Reactions

Adverse Reactions

Flushing of the face, neck, upper chest; tachycardia, hypotension, dyspnea, chest compression or tightness with higher doses.

Acthrel Clinical Trials

See Literature

Acthrel Note

Not Applicable

Acthrel Patient Counseling

See Literature