Acthrel Generic Name & Formulations
Corticorelin ovine (as the trifluoroacetate) 100mcg/vial; pwd for IV inj after reconstitution.
Corticotropin-releasing hormone (CRH) analogue.
For use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushings syndrome.
Acthrel Dosage and Administration
Adults and Children
Testing pituitary corticotrophin function: 1mcg/kg IV as a single dose. ACTH and cortisol response prolonged and remain elevated for up to 2 hours. Doses >1mcg/kg: not recommended. If repeat test needed, do tests at the same time of day as original test.
Acthrel Boxed Warnings
Higher doses associated with transient tachycardia, decreased BP, loss of consciousness, and asystole; symptoms may be reduced if given as a 30 second IV infusion instead of bolus inj. Pregnancy (Cat.C). Nursing mothers.
Plasma ACTH response inhibited by dexamethasone. Heparin to maintain IV cannula patency: not recommended.
Acthrel Adverse Reactions
Flushing of the face, neck, upper chest; tachycardia, hypotension, dyspnea, chest compression or tightness with higher doses.
Acthrel Clinical Trials
Acthrel Patient Counseling