• Poisoning/overdose

Acetadote Generic Name & Formulations

General Description

Acetylcysteine 200mg/mL; soln for IV infusion after dilution; preservative-free.

How Supplied

Single-use vial (30mL)—4

Generic Availability


Acetadote Indications


To minimize hepatic injury after acetaminophen overdose.

Acetadote Dosage and Administration

Adults and Children

Administer within 8 hours for maximal protection against hepatic injury. Estimate time of acetaminophen ingestion. If <24 hours since overdose, obtain serum acetaminophen level 4 hours post-ingestion or as soon as possible thereafter and plot level on nomogram, draw second level 4–6 hours after first; if either falls above toxicity line, initiate therapy. If >8 hours post-ingestion, start treatment immediately. If time of ingestion unknown: consider empiric initiation of treatment. 300mg/kg given as 3 separate doses and administered over a total of 21 hours. See full labeling for preparation based on patient weight. >100kg: loading dose: 15,000mg over 1 hour; first maintenance dose: 5,000mg over 4 hours; second maintenance dose: 10,000mg over 16 hours.

Acetadote Contraindications

Not Applicable

Acetadote Boxed Warnings

Not Applicable

Acetadote Warnings/Precautions


Asthma. History of bronchospasm. Monitor for severe hypersensitivity reactions; may treat with antihistamines and epinephrine; interrupt or discontinue treatment if persistent. Avoid fluid overload esp. in patients <40kg or those requiring fluid restriction; reduce volume of diluent as needed (see full labeling). Monitor liver enzymes, INR, creatinine, BUN, blood glucose, electrolytes. Hepatic or renal impairment: see full labeling. Pregnancy. Nursing mothers (pump and discard milk for 30hrs after therapy).

Acetadote Pharmacokinetics

See Literature

Acetadote Interactions

Not Applicable

Acetadote Adverse Reactions

Adverse Reactions

Hypersensitivity reactions (eg, rash, urticaria/facial flushing, pruritus, edema, hypotension, cough, wheezing, SOB, bronchospasm), GI upset, tachycardia.

Acetadote Clinical Trials

See Literature

Acetadote Note

Not Applicable

Acetadote Patient Counseling

See Literature