• CHF and arrhythmias

Ablysinol Generic Name & Formulations

General Description

Dehydrated alcohol ≥99% (by volume); soln for intra-arterial inj; preservative-free.

Pharmacological Class

Ablative agent.

How Supplied

Single-dose ampules (1mL, 5mL)—10

Generic Availability


Ablysinol Indications


To induce controlled cardiac septal infarction to improve exercise capacity in adults with symptomatic hypertrophic obstructive cardiomyopathy who are not candidates for surgical myectomy.

Ablysinol Dosage and Administration


Use minimum dose necessary to achieve desired reduction in peak LV outflow tract pressure gradient. Inject 1–2mL percutaneously over 1–2mins into septal arterial branches; max: 5mL per single procedure. Stop procedure if unable to reduce LV outflow tract pressure gradient to <10mmHg when reaching total dose of 5mL.


Not established.

Ablysinol Contraindications

Not Applicable

Ablysinol Boxed Warnings

Not Applicable

Ablysinol Warnings/Precautions


Should only be administered under supervision of a trained and experienced cardiologist. Transient or persistent heart block. Baseline PQ interval >160ms, baseline minimum HR <50bpm, baseline LV outflow gradient >70mmHg, max QRS during first 48hrs >155ms, 3rd-degree AV block during procedure, no clinical recovery between 12–48hrs post-op, >60yrs: risk for permanent pacemaker dependency. Increased risk of excessive tissue necrosis with higher volume used or higher number of septal branches injected to reduce LV outflow tract gradient. Perform continuous ECG monitoring for 48hrs post-op. Elderly. Pregnancy: not recommended; postpone until postpartum period. Nursing mothers.

Ablysinol Pharmacokinetics

See Literature

Ablysinol Interactions

Ablysinol Adverse Reactions

Adverse Reactions

Arrhythmias (eg, ventricular tachycardia, ventricular fibrillation); myocardial infarction.

Ablysinol Clinical Trials

See Literature

Ablysinol Note

Not Applicable

Ablysinol Patient Counseling

See Literature