Digoxin oral solution Rx

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Digoxin oral solution

CHF and arrhythmias
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Generic Name and Formulations:

Digoxin 0.05mg; per mL; lime-flavored; contains alcohol 10%.

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Indications for Digoxin oral solution:

Mild-to-moderate heart failure (with a diuretic and an ACE inhibitor when possible). Increase myocardial contractility in pediatrics with heart failure. Control of ventricular response rate in chronic atrial fibrillation.


Individualize: see full labeling. Initially 0.003mg/kg per day. Monitor digoxin levels.


Individualize: see full labeling. >2yrs: initially 0.01mg/kg per day. Monitor digoxin levels.


Ventricular fibrillation.


Renal dysfunction: reduce dose. Sinus node disease. Incomplete AV block. Accessory AV pathway (Wolff-Parkinson-White syndrome). Heart failure with preserved LV ejection fraction (eg, restrictive cardiomyopathy, constrictive pericarditis, amyloid heart disease, acute cor pulmonale, hypertrophic cardiomyopathy). Electrical cardioversion. Acute MI. Avoid in myocarditis. Toxicity risk increased by hypokalemia, hypomagnesemia, hypercalcemia, diabetes. Hypocalcemia may nullify effects. Thyroid disease. Hypermetabolic states. Monitor digoxin levels, electrolytes, renal function. Elderly. Children. Infants. Pregnancy (Cat.C). Nursing mothers.

Pharmacological Class:

Cardiac glycoside.


May be potentiated by antiarrhythmics (amiodarone, propafenone, quinidine), calcium channel blockers (verapamil, diltiazem, nifedipine, nitrendipine), captopril, telmisartan, spironolactone, carvedilol, epoprostenol, diclofenac, indomethacin, cyclosporine, ketoconazole, itraconazole, rabeprazole, clarithromycin. May be antagonized by rifampin, acarbose, miglitol, colestipol, St. John's Wort, albuterol. Increased risk of arrhythmias with sympathomimetics. Others (see full labeling).

Adverse Reactions:

GI upset, anorexia, CNS effects (eg, blurred or yellow vision, or mental disturbances, confusion, headache, weakness, dizziness, apathy), gynecomastia, rash, heart block, arrhythmias (esp. children).

How Supplied: