Digestive And Biliary Disorders

Avocado Implicated in Several Food Protein-Induced Enterocolitis Syndrome Cases

By October 29, 2018

FPIES is a gastrointestinal food-associated hypersensitivity that often affects infants and toddlers and is marked by vomiting, diarrhea, fatigue, and pallor.

Treatment for Alagille Syndrome Granted Orphan Drug Designation

By October 17, 2018

Alagille syndrome affects approximately 1 in 70,000 newborns.

Sucraid Supply Restored for Patients With Genetic Sucrase-Isomaltase Deficiency

By October 02, 2018

The Company stated that they are now able to meet all prescription demands for Sucraid without informed consent.

Drinking Water Turned Off in All Detroit's Public Schools

August 31, 2018

Recent tests revealed "higher than acceptable levels... (of) copper and/or lead" in at least 1 water source - such as a fountain or sink - at 16 of 24 schools, Vitti said.

FDA to Review Gimoti for Diabetic Gastroparesis in Adult Women

By August 16, 2018

The FDA has set a Prescription Drug User Fee Act target date of April 1, 2019.

Coffee Consumption and Pancreatitis Risk: What's the Link?

By July 27, 2018

For this meta-analysis, researchers searched for case-control, cross-sectional, or cohort studies that included keywords such as "coffee", "caffeine", and "pancreatitis" and compared the risk of pancreatitis based on coffee consumption.

A4250 Granted Rare Pediatric Disease Designation for Progressive Cholestasis

By June 13, 2018

The first patient has been enrolled in PEDFIC-1, a phase 3, single, randomized, double-blind, placebo-controlled trial designed to evaluate A4250 in 60 patients (aged 6 months-18 years) with PFIC subtype 1 or 2 who have elevated serum bile acid (sBA) levels and pruritus.

Addition of Bezafibrate Beneficial in Primary Biliary Cholangitis

June 13, 2018

The researchers found that 31% of the patients assigned to bezafibrate had a complete biochemical response (normal levels of total bilirubin, alkaline phosphatase, aminotransferases, and albumin as well as a normal prothrombin index) vs none assigned to placebo.

Ingestible Device Could Monitor Gastrointestinal Health

May 25, 2018

"IMBEDs enable new opportunities for gastrointestinal biomarker discovery and could transform the management and diagnosis of gastrointestinal disease," the authors write.

Homeopathic Products for Teething, Nausea, Colic, Cough Recalled

By May 18, 2018

Recalled products include Teething Drops, Nausea Drops, Intestinal Colic Drops, Stomach Calm, Expectorant Cough Syrup, Silver-Zinc Throat Spray, and Argentum Elixir.

Long-Term Obeticholic Acid Linked to Fibrosis Regression in PBC Patients

By April 13, 2018

Results showed that 46% (n=6) of substudy patients improved their histological fibrosis stage, while 38% maintained (n=5), and 15% experienced 1 stage progression (n=2).

DPP-4I Not Tied to Increased Risk of Acute Pancreatitis in Seniors

April 10, 2018

The researchers found that the risk of acute pancreatitis was not increased comparing 49,374 DPP-4I initiators with 132,223 sulfonylurea initiators and comparing 57,301 DPP-4I initiators with 32,612 thiazolidinedione initiators.

"Condom Challenge" Growing in Popularity Among Teens

By April 03, 2018

"As graphic as it is, we have to show parents because teens are going online looking for challenges and recreating them," said education specialist Stephen Enriquez.

Cimzia Label Update Provides New Information for Women of Childbearing Age

By March 22, 2018

Data added to the labeling includes first-of-their-kind pharmacokinetic studies demonstrating negligible to low transfer of CIMZIA through placenta and minimal transfer to breast milk from mother to infant.

Sollpura Falls Short in Exocrine Pancreatic Insufficiency Trial

By March 13, 2018

the Phase 3 'SOLUTION' study of Sollpura did not meet the primary endpoint of non-inferiority to an active-comparator in the coefficient of fat absorption (CFA).

Sudden Sensorineural Hearing Loss Recovery Lower in Metabolic Syndrome

February 16, 2018

The researchers found that the groups with and without metabolic syndrome had similar mean pure-tone audiometry thresholds at baseline but that recovery rates after treatment were significantly lower in the metabolic syndrome group.

Drinking Water Quality Violations Widespread, Says New Report

February 13, 2018

In locations of violation hot spots, repeat violations were prevalent, indicating that water systems struggle with recurring issues in these regions.

New Guidelines Focus on Early Treatment Decisions in Acute Pancreatitis

By February 12, 2018

The guidelines are intended to reduce practice variation and promote high-quality and high-value care.

Ocaliva Prescribing Information Updated to Reinforce Correct Dosing

By February 01, 2018

A table is included in the updated prescribing information to increase the prominence of the recommended Ocaliva dosage by disease stage and Child-Pugh classification.

Obeticholic Acid Monotherapy Leads to Jaundice in PBC Patient

By January 26, 2018

While OCA may be approved as monotherapy for PBC, the authors believe that clinicians should make sure that patients are truly not responding to UDCA before starting treatment.

Olmesartan Use Linked to Higher Rate of Enteropathy Compared to Other ARBs

By January 23, 2018

The authors note that while the evidence points to a higher rate of enteropathy outcomes in patients treated with olmesartan, the absolute rate was found to be low.

Swallowable Alternative to Endoscopy for Barrett's Esophagus Detection

January 23, 2018

The researchers found that for discriminating BE-related metaplasia and neoplasia cases versus normal individuals, CCNA1 DNA methylation had an area under the curve of 0.95, which was identical to that of VIM DNA methylation.

Pediatric Ulcerative Colitis Tx Granted Orphan Drug Status

By December 04, 2017

The designation is based on a review of Phase 1b clinical data which showed potential for SER-287 as a novel treatment modality for patients with UC

Fecal Microbial Transplant via Oral Capsule Versus Colonoscopy

November 29, 2017

The researchers found that prevention of recurrent CDI after a single treatment was achieved by 96.2% of participants in the capsule and colonoscopy groups in the per-protocol analysis (difference, 0%), meeting the criterion for noninferiority.

In ART-Treated HIV Patients With GI Discomfort, Consider EPI Assessment

By November 13, 2017

Of 100 participants, 32% had EPI (faecal elastase-1 <200 μg/g) and 20% severe EPI (faecal elastase-1 <100 μg/g).

Less Common Causes of Exocrine Pancreatic Insufficiency Explored

By November 13, 2017

Untreated celiac disease was also associated with EPI in 4% to 80% of cases but was resolved when patients adopted a gluten-free diet.

Haloperidol Plus Conventional Tx Effective for Symptomatic Gastroparesis

By October 26, 2017

Haloperidol was superior to placebo in reducing nausea and pain.

Fecal Transplant Efficacy Examined for Chronic Liver Disease

October 16, 2017

The researchers found that by week 26, three of six patients had a ≥50% decrease in alkaline phosphatase (ALP), with an average decrease of 250 versus 10 for responders versus nonresponders.

Post-Op Outcomes for Individualized vs. Standard Blood Pressure Tx

September 27, 2017

The researchers found that the primary outcome event occurred in 38.1 and 51.7% of patients assigned to the individualized treatment group and standard treatment strategy group, respectively.

Salt Intake Beliefs Examined in Patients Undergoing Hemodialysis

September 25, 2017

Patients who had versus those who had not received a transplant had a significantly higher score for the subscale of perceived seriousness for no reduction of sodium intake (P<0.01).