Diabetes

Dual-Hormone System May Lower Time in Hypoglycemia in T1DM

May 16, 2018

"The addition of glucagon delivery to a closed-loop system with automated exercise detection reduces hypoglycemia in physically active adults with type 1 diabetes," the authors write.

Gestational Diabetes May Indicate Future Subclinical Renal Issues

May 10, 2018

Women with a history of gestational diabetes had significantly higher estimated glomerular filtration rate, even if they had not subsequently developed diabetes.

Lesbian, Bi Women More Likely to Develop T2DM at Younger Age

May 09, 2018

Higher BMI in lesbian and bisexual women is an important contributor to the greater level of type 2 diabetes among this population, the authors found.

Exceptional Glycemic Control With Very Low-Carbohydrate Diet

May 09, 2018

The mean HbA1c was 5.67±0.66%. In the past year, only 2% of respondents reported diabetes-related hospitalizations, including 1% each for ketoacidosis and hypoglycemia.

Antipsychotic Use and Gestational Diabetes: Is There a Link?

By May 08, 2018

Results showed there was a significant crude risk linked to continuing vs discontinuing certain antipsychotics and developing gestational diabetes; for quetiapine the risk was 7.1% vs 4.1% (adjusted relative risk [ARR] 1.28), respectively; among olanzapine users it was 12% vs 4.7% (ARR 1.61), respectively.

Improved glycemic control in type 1 diabetics on very low-carbohydrate diets

May 08, 2018

A survey of individuals with type 1 diabetes mellitus (T1DM) consuming a very low-carbohydrate diet (VLCD) indicated that many study participants were able to maintain glycemic control within national ideal glycemic target ranges.

FDA: REMS No Longer Needed for Inhaled Insulin Afrezza

By May 03, 2018

Upon review of the proposed supplemental New Drug Application (sNDA), the FDA has determined that the communication plan is no longer needed as an element of the REMS to ensure the benefits of Afrezza outweigh its risks.

Glyburide Compared With Insulin for First-Line Tx of Gestational Diabetes

May 02, 2018

Frequency of primary outcome was 27.6 and 23.4 percent in glyburide and insulin groups, respectively

Irregular Menstruation Common in Girls With Type 2 Diabetes

April 30, 2018

These findings persisted after adjusting for body mass index. Treatment group had no effect on menses or sex steroids at 12 or 24 months. Furthermore, there was no association between sex steroids and measures of insulin sensitivity or secretion.

SGLT2 Inhibitors Canagliflozin, Dapagliflozin Compared in Real-World Study

By April 27, 2018

Researchers performed a retrospective cohort study by identifying patients from the Optum Clinformatics database who were initiated on canagliflozin 300mg or dapagliflozin 100mg from January 1, 2014 to September 30, 2016.

Hemoglobin A1c Levels Not Tied to Wound Outcomes

April 27, 2018

The researchers found that baseline A1C was not associated with wound healing in univariate or in fully adjusted models. In the participants with baseline A1C <7.5% (hazard ratio [HR], 2.07; 95% CI, 1.08 to 4.00), no association with wound healing was seen with the mean A1C change from baseline.

Aortic Stiffness, Concentric LV Remodeling Linked in T2DM

April 25, 2018

The researchers found that, compared with controls, participants with type 2 diabetes had increased LV mass, concentric LV remodeling, and lower AD.

Evening Preference Linked to Higher BMI in Type 2 Diabetes

April 24, 2018

The correlation between morning-evening preference and BMI was mediated by breakfast time; morning preference was correlated with earlier breakfast time and 0.37 kg/m² lower BMI.

SGLT-2 inhibitors and GLP-1 agonists associated with better mortality outcomes than DPP-4 inhibitors for T2D

April 20, 2018

SGLT-2 or GLP-1 agonists were associated with lower mortality than DPP-4 inhibitors, placebo, or no treatment.

Artificial Pancreas Treatment Efficacious for Type 1 Diabetes

April 20, 2018

Increased time in the near normoglycemic range and reduced time in hypo- and hyperglycemia

Young Adults With T1DM Show Muscle Metabolic Deficiencies

April 18, 2018

Participants with type 1 diabetes had an increase in the size and number of autophagic remnants in muscles; however, levels of the autophagic regulatory protein, phosphorylated AMP-activated protein kinase, and its downstream targets were similar between groups.

One-Hour Plasma Glucose Useful Predictor of Diabetic Retinopathy

April 16, 2018

The researchers found that the prevalence and incidence of DR changed in a similar manner across the distributions of 1h-PG and 2h-PG concentrations.

Soda Tax Cuts Daily Soda, Energy Drink Consumption

April 13, 2018

Compared to the control cities, within the first 2 months of tax implementation the odds of daily consumption in Philadelphia were lower for regular soda (odds ratio, 0.6) and energy drinks (odds ratio, 0.36), while consumption of bottled water was higher (odds ratio, 1.58).

Continuous Glucose Monitoring Cost-Effective in T1DM

April 13, 2018

A total of 158 patients with T1D and hemoglobin A1c (HbA1c) ≥7.5% were randomized in a 2:1 ratio to CGM versus control.

Pharmacists Can Help With Diabetes Management Via Telemedicine

April 13, 2018

Telemedicine could improve the situation of avoiding adverse events and ensuring proper day-to-day dosing by providing a real-time feedback loop, allowing clinical pharmacists to track data in real time.

Canagliflozin May Improve Renal Outcomes in Patients With T2D

By April 12, 2018

The renal protective benefit was seen in patients with both reduced (eGFR <60mL/min/1.73m2) and preserved (eGFR ≥60mL/min/1.73m2) renal function.

Higher Mortality Risk Seen for 'Night Owls'

April 12, 2018

Data were included in the study for 433,268 adults aged 38 to 73 years at the time of enrollment, who were followed for an average of 6.5 years.

FDA Approves Unique Device for Diabetic Retinopathy Screening

By April 11, 2018

This is the first device authorized for marketing that provides a screening decision without the need for clinician interpretation.

No Reduced CVD Risk for SBP &#60;120mmHg in Type 2 Diabetes

April 11, 2018

"Our findings support a SBP treatment target of 140mmHg and suspect no risk reduction attenuation on CVD for lower SBP targets," the authors write.

Eating Pecans May Cut Risk of Cardiovascular Disease, Diabetes

April 09, 2018

The researchers found that after 4 weeks on a pecan-rich diet, changes in serum insulin and homeostatic model assessment of insulin resistance and beta cell function were significantly greater compared to the control diet (P<0.05).

Lactation Lowers Risk of T2DM After Gestational Diabetes

April 05, 2018

By pooling data from three studies, long-term lactation (more than 1 to 3 months postpartum) was not associated with T2DM risk compared with no lactation (relative risk, 0.69; 95% confidence interval, 0.41 to 1.17).

Bydureon Single Dose Trays to Be Discontinued

By April 04, 2018

The 2mg Single Dose Tray presentation will be permanently discontinued on September 30, 2018.

Bydureon Approved for Use With Basal Insulin for Uncontrolled T2D

By April 03, 2018

The DURATION-7 study examined the effect of Bydureon or placebo as add-on therapy to insulin glargine, with or without metformin, in adults with T2D.

Islet Transplantation Improves Quality of Life in T1DM

March 29, 2018

There were also significant reductions in the Hypoglycemic Fear Survey total score and its two subscales (all P<0.0001) across all time points.

Add-On Antihypertensives Compared in Patients With Diabetes on ACEIs, ARBs

By March 28, 2018

The composite significant kidney event end point was defined as the first occurrence of ≥30% decline in eGFR to an eGFR <60mL/min/1.73m2, initiation of dialysis or kidney transplant.