Low-Energy Diet Induces Different Effects in Men, Women

August 15, 2018

Men had larger reductions in metabolic syndrome Z-score, C-peptide, fat mass, heart rate

Thyroid Dysfunction Linked to Gestational Diabetes

August 07, 2018

The researchers found that both fT3 and fT3-to-fT4 ratio were positively correlated with GDM (adjusted odds ratios, 4.25 and 3.89 comparing the highest versus the lowest fT3 quartile at first and second trimester, respectively).

Plasma Copeptin More Accurate for Diabetes Insipidus Diagnosis

August 06, 2018

"This prospective evaluation of patients with hypotonic polyuria validated hypertonic saline-stimulated copeptin measurement as a diagnostic method that appeared to be superior to the indirect water-deprivation test in distinguishing central diabetes insipidus from primary polydipsia," the authors write.

Nut Intake Reduces HbA1c Among Adults With T2DM

August 03, 2018

The researchers found that the full-dose nut diet provided 9.2% greater total energy intake from monounsaturated fat compared with the full-dose muffin diet.

Insulin analogs not tied with reduced hypoglycemia compared to NPH

August 02, 2018

In this retrospective cohort study, for patients with type 2 diabetes, initiation of a basal insulin analog compared with NPH insulin was not associated with a reduced risk of hypoglycemia-related ED visits or hospital admissions.

One in Four Older Adults With Diabetes Uses Alternative Meds

July 31, 2018

The researchers found that more than 2 million older adults with diabetes (25.0%) used some form of CAM in the past year in 2012.

FDA Approves FreeStyle Libre 14 Day Flash Glucose Monitoring System

By July 30, 2018

The new Flash Glucose Monitoring System enables patients to wear the sensor for up to 14 days compared with the existing FreeStyle Libre System that was approved for 10-day wear.

Sulfonylureas As 2nd-Line T2DM Therapy Tied to Higher Event Risk

July 24, 2018

The researchers found that over a mean follow-up of 1.1 years, sulfonylureas were associated with an increased risk of myocardial infarction, all-cause mortality, and severe hypoglycemia vs continuing metformin monotherapy.

Empagliflozin Does Not Up Risk of Bone Fractures

July 20, 2018

The researchers found that in the pooled analysis, bone fracture AEs were reported in 119 of 4221 patients (2.8%) randomized to empagliflozin 10mg, 105 of 4,196 patients (2.5%) randomized to empagliflozin 25mg, and 123 of 4203 patients (2.9%) randomized to the placebo group.

Results From Long-Term Cardiovascular Safety Study of Lorcaserin Announced

By July 19, 2018

Approximately 12,000 patients took part in the CAMELLIA-TIMI 61 trial in which participants were randomized to either lorcaserin HCl 10mg twice daily or placebo.

Trulicity Labeling Updated to Include Data on T2D Patients With CKD

By July 19, 2018

In the AWARD-7 trial, patients who received Trulicity 0.75mg or 1.5mg in combination with mealtime insulin lispro achieved similar glycemic control with weight loss vs patients who received traditional basal-bolus insulin.

New Data Support Long-Term Cardiovascular Safety of Linagliptin in T2D

By July 19, 2018

Results showed the overall safety profile of linagliptin in study patients, including adults with kidney disease, was consistent with previous data.

Basal Insulin Analogues Similar for Glucose Lowering

July 18, 2018

Thrice-weekly degludec (Deg-3TW) was inferior to most other regimens for reducing glycated hemoglobin levels, according to low- to very-low-quality evidence.

Canagliflozin Trial for T2D With CKD Stopped Early Due to Positive Results

By July 17, 2018

A clinical trial assessing canagliflozin (Invokana; Janssen) as an addition to standard-of-care in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) has been stopped early after meeting its pre-specified efficacy criteria.

FDA Extends Review Time for Invokana MACE Indication

By July 16, 2018

The application also includes the fixed-dose combinations, Invokamet (canagliflozin, metformin tablets) and Invokamet XR (canagliflozin, metformin extended-release tablets).

Two Regimens Fail to Stop Declines in β-Cell Function

July 13, 2018

The researchers observed no significant differences between treatment groups at baseline, 12 months, or 15 months in β-cell function, body mass index (BMI) percentile, hemoglobin A1c (HbA1c), fasting glucose, or oral glucose tolerance test 2-hour glucose results.

Does Basal Insulin Analog Use Reduce Hypoglycemia-Linked ER Visits?

July 13, 2018

No reduced risk of hypoglycemia-linked ER visits, admissions for basal insulin analog vs. NPH insulin

Circadian System, Misalignment Have Distinct Impact on Insulin

July 11, 2018

The researchers found that circadian phase and circadian misalignment impact glucose tolerance through different mechanisms.

FDA Strengthens Warnings for Fluoroquinolone Antibiotics

By July 10, 2018

The labeling changes are based on a review of postmarketing adverse event reports found in the FDA Adverse Event Reporting System (FAERS) database and published medical literature.

Calcium Channel Blocker May Benefit Patients With Type 1 Diabetes

By July 10, 2018

For this study, researchers conducted a randomized, double-blind, placebo-controlled Phase 2 trial (N=24) to assess the efficacy and safety of adding oral verapamil for 12 months to a standard insulin regimen in adults with recent-onset type 1 diabetes (age range: 18 to 45 years).

Oral Insulin Formulation Shows Promise in Early Studies

July 05, 2018

Significant, sustained decrease in blood glucose levels with low insulin doses of 3 to 10 U/kg

AMA Adopts Policy to Cut Sugar Sweetened Drink Consumption

July 03, 2018

Policy supports evidence-based strategies such as excise taxes, adding warning labels

Data Needed on New Type 2 Diabetes Therapies in Pregnancy

July 02, 2018

Scarce data on new glucose-lowering agents, with high risk for bias toward negative outcomes

Genetic Risk, Lifestyle Predict CVD, Diabetes Independently

June 28, 2018

A total of 339,003 unrelated individuals of white British descent with available genotype and matching genetic data from the UK Biobank cohort study were included in the study.

Idaho Pharmacists Able to Prescribe Meds for Several Conditions on July 1

By June 27, 2018

The new rule allows pharmacists to prescribe medications for cold sores, seasonal influenza, strep throat, and urinary tract infections, as well as statins for patients with diabetes.

Beta-Blockers Show Varied Effects on Hypoglycemic Mortality Risk in Diabetes

June 27, 2018

Investigators examined the relationship between the use of β-blockers and incidence of hypoglycemia and risk for mortality in hospitalized patients with diabetes.

Hepatitis B Vaccines Compared in Older Adults With Type 2 Diabetes

By June 26, 2018

For the analysis, study authors looked at data specifically for patients with type 2 diabetes aged 60 to 70 years.

Risk for Below Knee Amputations Compared Among Antihyperglycemic Agents

June 26, 2018

Investigators analyzed real world data to examine the risk for below-knee amputations in patients with type 2 diabetes taking canagliflozin vs other medications.

Insulin Glargine 300 Safe, Effective in Seniors With T2DM

June 26, 2018

The researchers found that from baseline to week 26, the reductions in HbA1c were comparable for Gla-300 and Gla-100 in the overall population and for participants aged ≥75 years.

MiniMed 670G System Approved for Use in Younger Patients With T1D

By June 25, 2018

The MiniMed 670G system measures glucose levels every 5 minutes and automatically adjusts insulin delivery to avoid highs and lows.