"The addition of glucagon delivery to a closed-loop system with automated exercise detection reduces hypoglycemia in physically active adults with type 1 diabetes," the authors write.
Women with a history of gestational diabetes had significantly higher estimated glomerular filtration rate, even if they had not subsequently developed diabetes.
Higher BMI in lesbian and bisexual women is an important contributor to the greater level of type 2 diabetes among this population, the authors found.
The mean HbA1c was 5.67±0.66%. In the past year, only 2% of respondents reported diabetes-related hospitalizations, including 1% each for ketoacidosis and hypoglycemia.
Results showed there was a significant crude risk linked to continuing vs discontinuing certain antipsychotics and developing gestational diabetes; for quetiapine the risk was 7.1% vs 4.1% (adjusted relative risk [ARR] 1.28), respectively; among olanzapine users it was 12% vs 4.7% (ARR 1.61), respectively.
A survey of individuals with type 1 diabetes mellitus (T1DM) consuming a very low-carbohydrate diet (VLCD) indicated that many study participants were able to maintain glycemic control within national ideal glycemic target ranges.
Upon review of the proposed supplemental New Drug Application (sNDA), the FDA has determined that the communication plan is no longer needed as an element of the REMS to ensure the benefits of Afrezza outweigh its risks.
These findings persisted after adjusting for body mass index. Treatment group had no effect on menses or sex steroids at 12 or 24 months. Furthermore, there was no association between sex steroids and measures of insulin sensitivity or secretion.
Researchers performed a retrospective cohort study by identifying patients from the Optum Clinformatics database who were initiated on canagliflozin 300mg or dapagliflozin 100mg from January 1, 2014 to September 30, 2016.
The researchers found that baseline A1C was not associated with wound healing in univariate or in fully adjusted models. In the participants with baseline A1C <7.5% (hazard ratio [HR], 2.07; 95% CI, 1.08 to 4.00), no association with wound healing was seen with the mean A1C change from baseline.
The researchers found that, compared with controls, participants with type 2 diabetes had increased LV mass, concentric LV remodeling, and lower AD.
The correlation between morning-evening preference and BMI was mediated by breakfast time; morning preference was correlated with earlier breakfast time and 0.37 kg/m² lower BMI.
SGLT-2 inhibitors and GLP-1 agonists associated with better mortality outcomes than DPP-4 inhibitors for T2D
SGLT-2 or GLP-1 agonists were associated with lower mortality than DPP-4 inhibitors, placebo, or no treatment.
Participants with type 1 diabetes had an increase in the size and number of autophagic remnants in muscles; however, levels of the autophagic regulatory protein, phosphorylated AMP-activated protein kinase, and its downstream targets were similar between groups.
The researchers found that the prevalence and incidence of DR changed in a similar manner across the distributions of 1h-PG and 2h-PG concentrations.
Compared to the control cities, within the first 2 months of tax implementation the odds of daily consumption in Philadelphia were lower for regular soda (odds ratio, 0.6) and energy drinks (odds ratio, 0.36), while consumption of bottled water was higher (odds ratio, 1.58).
Telemedicine could improve the situation of avoiding adverse events and ensuring proper day-to-day dosing by providing a real-time feedback loop, allowing clinical pharmacists to track data in real time.
The renal protective benefit was seen in patients with both reduced (eGFR <60mL/min/1.73m2) and preserved (eGFR ≥60mL/min/1.73m2) renal function.
Data were included in the study for 433,268 adults aged 38 to 73 years at the time of enrollment, who were followed for an average of 6.5 years.
This is the first device authorized for marketing that provides a screening decision without the need for clinician interpretation.
"Our findings support a SBP treatment target of 140mmHg and suspect no risk reduction attenuation on CVD for lower SBP targets," the authors write.
The researchers found that after 4 weeks on a pecan-rich diet, changes in serum insulin and homeostatic model assessment of insulin resistance and beta cell function were significantly greater compared to the control diet (P<0.05).
By pooling data from three studies, long-term lactation (more than 1 to 3 months postpartum) was not associated with T2DM risk compared with no lactation (relative risk, 0.69; 95% confidence interval, 0.41 to 1.17).
The DURATION-7 study examined the effect of Bydureon or placebo as add-on therapy to insulin glargine, with or without metformin, in adults with T2D.
There were also significant reductions in the Hypoglycemic Fear Survey total score and its two subscales (all P<0.0001) across all time points.
The composite significant kidney event end point was defined as the first occurrence of ≥30% decline in eGFR to an eGFR <60mL/min/1.73m2, initiation of dialysis or kidney transplant.