Diabetes YIR 2017

Does Antibiotic Use Increase the Risk of Diabetes?

December 05, 2017

The researchers found that while more cases than controls received at least 6 courses of antibiotics (17.9 versus 13.8%), the association between antibiotic use and risk of diabetes was progressively reduced when clinical and lifestyle factors were accounted for.

T2DM Treatment Adherence Compared Across Drug Classes

December 04, 2017

Adherence better for sulfonylureas and thiazolidinediones compared with metformin

HbA1c-Lowering Effects of DPP4i Therapy May Be Blunted by Diet

December 01, 2017

Multiple regression analyses revealed that fat intake, especially saturated fat intake, was significantly correlated with ΔHbA1c.

Body Surface Area Affected by Psoriasis May Be Linked to T2DM Risk

By November 20, 2017

To determine the risk of T2DM, researchers compared adults with psoriasis (n=8124), grouping them by affected BSA, to those without psoriasis (n=76,599); patients were followed for ~4 years.

Serious Hypoglycemia Risk Compared Among Oral Antidiabetics

By November 07, 2017

Among all study drugs, the highest rate was seen with glyburide.

'Type 3c' Diabetes Often Mislabeled as Type 2

By October 25, 2017

The data showed diabetes following pancreatic disease was more common than type 1 diabetes (2.59 [95% CI: 2.38-2.81] per 100,000 person-years vs. 1.64 [95% CI: 1.47-1.82]; P<0.001). These cases of diabetes following pancreatic disease (n=559) were primarily classified by clinicians as type 2 diabetes.

Statin Use May Up Diabetes Risk in Higher Risk Patients

October 24, 2017

Researchers assessed incident diabetes by annual 75g oral glucose tolerance testing and semiannual fasting glucose among 3,234 participants enrolled in the Diabetes Prevention Program Outcomes Study.

Bydureon BCise Gets FDA Approval for Type 2 Diabetes

By October 23, 2017

In clinical trials, treatment with Bydureon BCise resulted in average HbA1c reductions of up to 1.4% and average weight loss of up to 3.1 pounds when used as monotherapy or as an add-on to metormin, a sulfonylurea, a thiazolidinedione, or any combination of two of these agents, at 28 weeks.

Hypoglycemic Events Up When Sulfonylurea Added to Insulin Monotherapy

October 18, 2017

Researchers found an approximate 1% decrease in HbA1c with the addition of a sulfonylurea or metformin to insulin.

Prefilled, Disposable Insulin Pen With Half-Unit Dosing Now Available

By October 12, 2017

The Humalog Junior KwikPen is lighter and shorter than other half-unit insulin pens.

Can Frequent Mouthwash Use Up the Risk of Prediabetes/Diabetes?

By October 06, 2017

Study authors explained that using antibacterial mouthwash can eradicate oral microbes needed for nitric oxide formation and place the user at risk for metabolic disorders.

Do SGLT2 Inhibitors Increase Cancer Risk in T2D Patients?

October 06, 2017

Overall cancer risk not increased compared with placebo, other active glucose-lowering treatments

New Glucose-Sensing Device Eliminates Need for Routine Finger Sticks

By September 29, 2017

A trial (Dunn T et al. 2017) of ≥50,000 diabetes patients, that lasted 18 months, found that FreeStyle Libre users checked their glucose on average 16 times a day.

FDA Approves Fiasp for Patients with Type 1, Type 2 Diabetes

By September 29, 2017

Fiasp is formulated with niacinamide which helps increase the speed of the initial insulin absorption.

Do SGLT2 Inhibitors Raise the Risk of Lower Extremity Amputation?

By September 15, 2017

Study authors analyzed the occurrence of amputation in patients with type 2 diabetes mellitus treated with SGLT2 inhibitors vs. non-SGLT2 inhibitors, and specifically, canagliflozin.

Victoza Approved to Reduce Risk of MACE

By August 28, 2017

The Food and Drug Administration (FDA) approval was based on data from the randomized, double-blind, placebo-controlled LEADER trial (n=9,340) that evaluated long-term effects of Victoza vs. placebo in patients with type 2 diabetes with high risk of major cardiovascular events (MACE).

Relationship Between Sleep Duration and T2D Risk Examined in Children

August 15, 2017

A one-hour longer sleep duration correlated with 0.19 kg/m² lower body mass index, 0.03 kg/m5 lower fat mass index, 2.9% lower homeostasis model assessment of insulin resistance, and 0.24% lower fasting glucose.

Alcohol Consumption May Play a Role in Diabetes Risk

July 31, 2017

Wine appears to provide the most protective benefit, researchers say

PCP Survey Reveals Most Don't Know All the Risk Factors for Prediabetes

July 26, 2017

Fewer than one in 10 PCPs surveyed named all risk factors identified by American Diabetes Association

Diabetes Treatments Compared for Bladder Cancer Risk

By July 17, 2017

The greatest incidence of bladder cancer was among the group who initiated pioglitazone treatment, in which there were 308 cases per 100,000 person-years.

Review: Diabetic Foot Ulcer Treatments Compared

By June 27, 2017

Participants in the antimicrobial-dressing treatment arm experienced an additional 119 healing events. However, the researchers considered this "low-certainty evidence," due to risk of bias.

Type 1 Diabetes Reversal May Be Possible with TB Vaccine

By June 13, 2017

Faustman's team is preparing for a 5-year, 150-person Phase 2 trial to investigate the potential for repeat BCG vaccination to improve type 1 diabetes in adults with existing disease.

Diabetes Drug Class Linked to Increased Ketoacidosis Risk

June 08, 2017

Associated with approximately twice the risk of DKA compared to DPP4 inhibitors

Does Antioxidant Supplementation Slow Diabetic Kidney Disease Progression?

By June 02, 2017

Since oxidative stress is known to worsen DKD, study authors sought to review available data on the possible benefits of chronic antioxidant supplementation on DKD progression.

Certain Antidiabetic Agents Linked to Increased Pneumonia Risk

By April 17, 2017

Results showed that compared with current use of metformin + sulfonylurea, the use of thiazolidinediones + metformin was associated with an increased risk of CAP.

Synjardy XR Launched for Type 2 Diabetes

By April 14, 2017

Both Synjardy and Synjardy XR should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. It carries a boxed warning regarding metformin-associated lactic acidosis.

Diabetic Peripheral Neuropathy Treatments Explored

March 27, 2017

The researchers identified an additional 24 published studies and 25 unpublished studies, since the last completed systematic review of 57 eligible studies.

Outdoor Temps May Have an Impact on Diabetes Incidence

March 22, 2017

The researchers found that, on average, age-adjusted diabetes incidence increased 0.314 per 1,000 per 1 degree Celsius increase in temperature.

FDA Approves Qtern for Type 2 Diabetes

By February 28, 2017

Qtern should only be used in patients who tolerate dapagliflozin 10mg.

Omega-3 Consumption and Type 2 Diabetes: What's the Link?

January 05, 2017

Consumption of single omega-3 is associated with an increased risk of type 2 diabetes (T2D), with dosage, ethnicity, trial duration, and recruited age influencing the effect, according to a meta-analysis published online December 29 in the Journal of Diabetes Investigation.