The Role of Hedgehog Pathway Inhibition in Advanced Basal Cell Carcinoma

Even with a very high rate of cure through standard techniques (up to 95%) such as surgical excision, Dirk Schadendorf, MD, professor of dermatology, University Hospital Essen, Essen, Germany, discusses the treatment of more difficult basal cell carcinoma cases that involve relapse, difficult location, late detection, and other more problematic issues.

Nicole Basset-Seguin, MD, PhD, Policlinique de Dermatologie, Hôpital Saint-Louis, Paris, France discusses previous treatment methods and the new possibilities that have come about due to the discoveries related to the function of the hedgehog pathways and the benefits of hedgehog pathway inhibitors.

Aleksandar Sekulic, MD, PhD, assistant professor, dermatology, Mayo Clinic Scottsdale, Translational Genomics Institute, Scottsdale AZ, expands upon the role of the development of hedgehog pathway inhibitors and their progress through the various stages of clinical trials.