Depression

ECT Effective for Treatment-Resistant Depression

May 15, 2018

ECT was projected to reduce time with uncontrolled depression from 50 to 33 to 37% of life-years over 4 years; greater improvements were seen when ECT was offered earlier.

Positive Results Announced for Esketamine in Treatment-Resistant Depression

By May 07, 2018

In both studies, the primary efficacy endpoint was change from baseline to Day 28 in Montgomery-Åsberg Depression Rating Scale (MADRS) total score.

Antidepressant Medications and Headache: Is There a Link?

By May 03, 2018

Compared to placebo, selective serotonin reuptake inhibitors (SSRIs) were associated with a significantly higher risk of headache (risk ratio [RR] 1.06, 95% CI: 1.00 to 1.13; P =.045).

Trintellix Labeling Updated With Data on Improved Processing Speed in MDD

By May 03, 2018

The approval was based on data from the 8-week, randomized, double-blind, placebo-controlled studies, FOCUS and CONNECT, which investigated the effect of Trintellix on various aspects of cognitive function among adults aged 18 to 65 years with depression.

NDA Submitted for Postpartum Depression Treatment Brexanolone

By April 23, 2018

Results in the 202B and 202C trials showed that brexanolone achieved the primary endpoint of mean reduction from baseline in the Hamilton Rating Scale for Depression.

FDA to Review Opioid System Modulator for Major Depressive Disorder

By April 16, 2018

ALKS 5461 consists of a fixed-dose combination of buprenorphine, a partial mu-opioid receptor agonist and kappa-opioid receptor antagonist, and samidorphan, a mu-opioid receptor antagonist.

<i>DSM-5</i>-Defined Major Depressive Disorder Highly Prevalent Among U.S. Adults

By March 21, 2018

To determine the prevalence of DSM-5 MDD as well as DSM-5 specifiers, the study authors conducted "in-person interviews with a representative sample of US noninstitutionalized civilian adults (≥18 years) (n = 36 309) who participated in the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions III (NESARC-III)."

Progestin-Only Contraceptives and Depression: Is There a Link?

By February 28, 2018

Study quality was graded according to the United States Preventive Services Task Force and the Cochrane Risk of Bias Tools.

Serotonin Syndrome Risk Assessed With Concomitant Triptan, SSRI/SNRI Use

February 27, 2018

Researchers question FDA advisory warning on risk of concomitant use

CDC: Prevalence of Depression Examined Among U.S. Adults

February 14, 2018

Depression more common in women; lower among non-Hispanic Asians than other ethnic groups

NDA for Novel Major Depressive Disorder Treatment Submitted to FDA

By January 31, 2018

The NDA submission is based on a comprehensive clinical efficacy and safety package with data from more than 30 clinical trials.

Are Psychiatric Drugs Being Overprescribed in Children and Adolescents?

By January 30, 2018

"Our results show that, at a population level, prescriptions of stimulants and antidepressant medications for children and adolescents do not appear to be prescribed at rates higher than the known rates for psychiatric conditions they are designed to treat," said the study's lead author, Dr. Ryan Sultan.

Ketamine May Have 'Rapid' Effect on Suicidal Ideation in Depressed Patients

By December 15, 2017

The ketamine-treated patients demonstrated a clinically significant reduction in suicidal thoughts compared to the midazolam-treated patients within 24 hours (4.96 points greater reduction in SSI, 95% CI: 2.33, 7.59).

Sleep Deprivation: An Effective Antidepressant?

By September 21, 2017

Researchers from the Perelman School of Medicine at the University of Pennsylvania analyzed 66 studies to determine the antidepressant effects of sleep deprivation.

Recall: Antipsychotic Tablets Found in Antidepressant Bottle

By August 29, 2017

A Health Hazard Evaluation indicated a high risk to the patient ingesting the foreign tablet.

Sleep Duration Linked to Tx Response in Depressed Patients with Insomnia

By June 05, 2017

Findings from the study suggest that a shorter sleep duration may be a risk factor for refractory depression.

Dietary Supplement May Reduce Vulnerability to Postpartum Blues

March 14, 2017

Supplement designed to counter functions of elevated monoamine oxidase activity

Antidepressants Evaluated for Different Symptoms of Depression

February 28, 2017

Most drugs more effective for core emotional symptoms than for sleep, atypical symptoms

Antidepressants Often Prescribed for Unapproved Uses

February 23, 2017

Trazodone for insomnia most common off-label use for antidepressants

Do Pre-Existing Psychiatric Conditions Impact Opioid Use?

By December 29, 2016

Study authors reported evidence of greater opioid receipt among commercially insured patients with a wide range of psychiatric conditions.

Top 10 Most Costly Conditions in the U.S. Announced in New Report

By December 27, 2016

The highest amounts of spending were seen with these 10 conditions.

Treatment Combo Benefits Patients with Late-Life Depression

November 23, 2016

Characteristics associated with remission for AD PE include age 75 years and older, polypharmacy

Anxiety, Depression Significantly Higher in Those With Hyperhidrosis

November 21, 2016

Hyperhidrosis (HH) is associated with increased prevalence of anxiety and depression, in a HH severity-dependent manner, according to a study published in the Journal of the American Academy of Dermatology.

Arthritis Drug May Help Improve Antidepressant Response

By November 11, 2016

Adding celecoxib to antidepressant therapy may improve its effectiveness in bipolar patients who have been treatment resistant.

Depression Care Management Processes Severely Lacking

March 14, 2016

U.S. primary care practices use less than one care management process for depression, on average, according to a study published in the March issue of Health Affairs.

Depression Screening for all Adults, Recommends USPSTF

January 27, 2016

The US Preventive Services Task Force (USPSTF) recommends depression screening in the general adult population, including pregnant and postpartum women. These findings form the basis of a final recommendation statement published in the Journal of the American Medical Association.

Cognitive Therapy and Meds; Equally Effective for Major Depression

December 10, 2015

Cognitive behavioral therapy and antidepressants could both be equally effective as stand-alone treatments for major depressive disorder.

AAP: Screen All Children for Cholesterol, Depression, HIV

December 08, 2015

All children should be screened for high cholesterol, depression, and HIV, with some tests starting as early as age 9, according to new guidelines from the American Academy of Pediatrics published online December 7 in Pediatrics.

Omega-3 Fatty Acids May Play Role in Bipolar Disorder

December 07, 2015

There may be a link between levels of omega-3 fatty acids and bipolar disorder, according to a small study published in the November issue of Bipolar Disorders.

Antidepressants Don't Adversely Affect Tamoxifen Efficacy

By December 07, 2015

Breast cancer survivors who take antidepressants while on tamoxifen are not at increased risk for cancer recurrence, according to research published online December 1 in the Journal of the National Cancer Institute.