Recurrent Salmonella enterica Typhimurium infection disables host protection against intestinal inflammation
Repeated gastrointestinal infections in mice, in this case Salmonella enterica Typhimurium (ST), caused intestinal tissue inflammation which escalated with repeated infections.
Firvanq oral solution will replace CutisPharma's FIRST-Vancomycin Unit-of-Use Compounding Kit, which was used by pharmacists to compound vancomycin oral liquid.
Apart from a single amino acid substitution, Trulance is structurally identical to human uroguanylin and is thought to replicate the pH-sensitive activity of uroguanylin.
The authors note that while the evidence points to a higher rate of enteropathy outcomes in patients treated with olmesartan, the absolute rate was found to be low.
The researchers found that over a 12-week period there was a significant reduction in stoma-related cost of care with use of the ceramide-infused barrier, resulting in a 14% relative decrease in cost.
Mr. C, a 30-year-old male with Crohn's disease, presented to his clinician with symptoms of fatigue, lethargy, headaches, pallor, hair loss, irritability, and weakness.
Those treated with accelerated (AI) versus standard infliximab induction strategies had a numerically higher colectomy rate; however, AI treatment was correlated with more severe biochemical disease.
Results showed that disease activity scores before and after switching were not statistically significantly different (Crohn's disease activity index: P=.5657 and Truelove-Witts disease activity index: P=.7609).
The researchers found that PIE and sodium phosphate were superior to PEG, with both receiving a score of 4 on a 5-point scale (blind assessment), versus a 3 for PEG (P<0.01).
The designation is based on a review of Phase 1b clinical data which showed potential for SER-287 as a novel treatment modality for patients with UC
Results of the review also found that 18 adverse events occurred in a total of 13 patients (18.1% of patients; 6.6% of infusions).
The researchers found that prevention of recurrent CDI after a single treatment was achieved by 96.2% of participants in the capsule and colonoscopy groups in the per-protocol analysis (difference, 0%), meeting the criterion for noninferiority.
The number of reactions before diagnosis was four on average. The main symptoms at the debut were vomiting and vomiting with diarrhea (97.5 and 30%, respectively), which occurred in a mean time of 126.3 minutes after ingestion of the culprit fish.
A Phase 2 trial demonstrated how glepaglutide treatment was associated with reduced fecal wet weight output as well as indicated increases in energy, fluid and electrolyte absorption.
The researchers found that ever being breastfed was associated with a lower risk of CD and UC (OR 0.71, 95% CI 0.59-0.85 and OR 0.78, 95% CI 0.67-0.91 respectively).
Cx601 is a first-in-class allogeneic cell therapy intended for patients who have had an inadequate response to at least one conventional or biologic therapy.
Despite its frequency, iron deficiency anemia in patients with IBD it is often overlooked in clinical settings.
The 35-year-old male from Hawaii maintained clinical remission with Lialda, a once-daily formulation of mesalamine, and infliximab.
Results showed that adenoma detection rate (ADR) did not differ between groups. Additionally willingness to repeat and tolerability did not differ.
By measuring drug and antibody concentrations physicians can adapt treatment strategies and guide patients toward more personalized medicine.
The PROMETHEUS Monitr Crohn's Disease test can be used as an adjunct to endoscopy or by itself between endoscopies.
These 2 cases suggests that fecal transplants can have a profound immunological response not only limited to intestinal effects, say the authros.
In addition, the researchers assayed umbilical cord blood samples from 33 infants to assess the concentration of biologic agents.
The results showed a higher proportion of patients with GI symptoms on clopidogrel (68%) compared to controls (60%, P=0.0011) that were Females (70% vs. 60%, P=0.0003) not Males (61 vs. 60%; P=0.8312).
Early Phase 1 data has indicated that the treatment drug can be more efficacious than mesalamine/5-ASA treatments alone.
An FDA inspection of the clinic found that adipose tissue was being processed into stromal vascular fraction (stem cells derived from body fat) which was then administered intravenously or directly into the spinal cord of patients.