Colorectal And GI Cancers

ASCO: Sunitinib Alone Noninferior in Metastatic Renal Cell Cancer

June 05, 2018

The median overall survival was 18.4 and 13.9 months in the sunitinib-alone and nephrectomy-sunitinib groups, respectively. There were no significant between-group differences in response rate or progression-free survival.

Hepatocellular Carcinoma Rate with Long-Term Entecavir/Tenofovir Tx

June 21, 2017

Older age, lower platelets at baseline and year five, liver stiffness 12 kPa linked to HCC development

Genetics Should Play a Bigger Role in Clinical Decision-Making

June 21, 2017

As home genetic testing grows, patients will be bringing their results to physicians for reaction and response. Physicians will need to be proactively prepared.

Nut Consumption Linked to Survival in Colon Cancer Patients

May 18, 2017

The researchers found that patients who adhered closely to the guidelines regarding exercise, diet, and excess weight had a 42% lower mortality risk than those who didn't.

FDA Gives Green Light to Stivarga HCC Indication

By April 27, 2017

A trial involving 573 patients with HCC whose tumors progressed after receiving sorafenib demonstrated the safety and efficacy of Stivarga in this population.

Aspirin Use Linked to Reduced Risk of Cancer Death

April 04, 2017

The researchers found that regular aspirin use correlated with reduced risk of total mortality compared with nonregular use (multivariable-adjusted relative risks [RRs], 0.93 and 0.89 for women and men, respectively).

Clinician Fails to Follow Up on Crucial Information

By March 02, 2017

This case examines a situation where a physician did not act on a bit of information that he should have taken quite seriously.

Year-on-Year Rise in Colorectal CA Rates Among Twenty-Somethings

March 01, 2017

Americans in their early 50s and younger are experiencing significant increases in colorectal cancer incidence, according to research published online February 28 in the Journal of the National Cancer Institute.

Colorectal CA Prevalence Among Metabolically Healthy, Unhealthy Women

February 02, 2017

Even normal-weight women may be at greater risk for colorectal cancer if they have certain traits, such as elevated triglycerides, low high-density lipoprotein cholesterol, elevated blood pressure, and elevated fasting glucose

Moderate Daily Exercise May Improve Survival Among CRC Patients

January 18, 2017

Just a half hour a day of moderate physical activity could improve survival odds for patients with metastatic colorectal cancer (CRC), according to a study presented at the American Society of Clinical Oncology's annual Gastrointestinal Cancers Symposium, held from January 19 to 21 in San Francisco.

Work-Related Stress May Be Tied to Certain Cancers

By January 17, 2017

Prolonged work-related stress in men has been tied to increased chances of cancer at five sites; lung, colon, rectal, stomach and lymphatic.

Adjunct EGFR-Blocker Assessed for Locoregional Failure in Anal CA

January 17, 2017

Addition of cetuximab to chemoradiation (CRT) is associated with a reduction in locoregional failure (LRF) rates in squamous cell carcinoma of the anal canal (SCCAC), according to a study published online January 9 in the Journal of Clinical Oncology.

Hepatitis Status May Impact HCC Treatment Efficacy

January 09, 2017

For patients with advanced unresectable hepatocellular carcinoma, the effect of sorafenib on overall survival (OS) is dependent on patients' hepatitis status, according to a meta-analysis published online January 3 in the Journal of Clinical Oncology.

Priority Review Granted to Potential Liver Cancer Treatment

By January 04, 2017

Bayer has announced that their supplemental New Drug Application (sNDA) for Stivarga (regorafenib tablets) has been granted priority review status by the Food and Drug Administration (FDA).

Cetuximab Evaluated in HIV-Associated Anal Cancer

December 14, 2016

Definitive chemoradiation (CRT) can potentially cure HIV-associated squamous cell carcinoma of the anal canal (SCCAC), with the addition of cetuximab resulting in less locoregional failure (LRF), according to a study published online December 12 in the Journal of Clinical Oncology.

Case: Metastatic CRC Regresses After Treatment Targeting KRAS G12D

December 09, 2016

Administration of cytotoxic T-cells targeting mutant KRAS G12D can induce tumor regression in metastatic colorectal cancer, according to a case report published in the New England Journal of Medicine.

Trastuzumab Biosimilar BLA Submitted to FDA

By November 08, 2016

Mylan and Biocon announced the submission of a Biologics License Application (BLA) to the Food and Drug Administration (FDA) for MYL-141O, the proposed biosimilar to trastuzumab.

Insulin-Related CA Risks May Be Offset by Statin Use

October 26, 2016

For patients with type 2 diabetes mellitus (T2DM), use of statins offsets insulin-related cancer risks, according to research published online in the Journal of Internal Medicine.

FDA Grants Orphan Drug Status to Novel Hepatocellular Carcinoma Tx

By October 24, 2016

Yisheng Biopharma has announced that the Food and Drug Administration (FDA) has granted orphan drug designation for its candidate hepatocellular carcinoma treatment, YS-ON-001.

Prognostic Value of Retrieved Lymph Node Number Examined in Gastric Cancer

September 30, 2016

In patients with pathological stage (pStage) II or III gastric cancer, the number of retrieved lymph nodes (RLNs) is an independent poor prognostic factor, according to a study published inthe Journal of Gastroenterology and Hepatology.

Diabetes Drug Adherence Examined Among Cancer Patients with T2DM

By July 25, 2016

Among patients with cancer, researchers found a high prevalence of non-adherence to oral antidiabetic medications and negative consequences tied with non-adherence.

<sup>125</sup>I Brachytherapy Implantation Significantly Ups Anastomotic Leakage in Rectal CA

June 06, 2016

For patients with rectal carcinoma, intraoperative iodine-125 seed implantation brachytherapy is associated with increased risk of anastomotic leakage (AL) and pelvic autonomic nerve dysfunction, according to a study published in the June issue of the Journal of Gastroenterology and Hepatology.

Side of Colon Tumor Development Can Impact Survival Length in CRC

May 20, 2016

Survival odds for colorectal cancer may depend on which side of the colon the primary tumor develops, according to a study released Wednesday during a media briefing that previewed some of the research to be presented at the upcoming annual meeting of the American Society of Clinical Oncology.