Chlorzoxazone Rx

Select the drug indication to add to your list


Musculoskeletal pain
Only 4 drugs may be compared at once

Generic Name and Formulations:

Chlorzoxazone 375mg, 750mg+; tabs; +scored.

Select therapeutic use:

Indications for Chlorzoxazone:

As adjunct to rest, physical therapy, and other measures in acute, painful musculoskeletal conditions.


375mg: 1 tab 3–4 times daily; may increase to 2 tabs (750mg) 3–4 times daily if inadequate response. 750mg: ⅓ tab (250mg) 3–4 times daily. Painful musculoskeletal conditions: initially ⅔ tab (500mg) 3–4 times daily; may increase to 1 tab (750mg) 3–4 times daily if inadequate response. May reduce dose based on improvement.


Not recommended.


Known drug intolerance.


Monitor for hepatotoxicity; discontinue if hepatic dysfunction or abnormal liver enzymes develop. Known allergies or history of. Discontinue if sensitivity reaction occurs. Pregnancy.

Pharmacological Class:

Muscle relaxant (central).


Additive effects with concomitant alcohol, other CNS depressants.

Adverse Reactions:

Drowsiness, dizziness, lightheadedness, malaise, overstimulation; rare: skin rash, petechiae, ecchymosis, fatal hepatocellular toxicity.


Formerly known under the brand name Lorzone, Paraflex.

How Supplied:

Contact supplier