CHF And Arrhythmias

Tafamidis improves all-cause mortality in transthyretin amyloid cardiomyopathy

September 21, 2018

In a phase 3 randomized control trial, tafamidis was shown to have associations with greater reductions in all-cause mortality and cardiovascular related hospitalizations compared to placebo among participants with transethyretin amyloid cardiomyopathy.

Tafamidis Treats Transthyretin Amyloid Cardiomyopathy

September 18, 2018

Tafamidis was also associated with a lower rate of decline in distance for the 6-minute walk test and a lower rate of decline in Kansas City Cardiomyopathy Questionnaire-Overall Summary score at month 30.

Use of Aspirin in Healthy Elderly Questioned in Three Studies

September 17, 2018

The researchers found that the rate of cardiovascular disease was 10.7 and 11.3 events per 1000 person-years in the aspirin and placebo groups, respectively (hazard ratio, 0.95; 95% confidence interval, 0.83 to 1.08).

Second Impurity Identified in Recalled Valsartan Products

By September 17, 2018

In July, several valsartan medications were recalled due to the detection of N-nitrosodimethylamine, an impurity classified as a probable human carcinogen.

Praliciguat Gets Fast-Tracked for Heart Failure With Preserved Ejection Fraction

By September 17, 2018

The Company is currently enrolling patients in a randomized, double-blind, placebo-controlled Phase 2 trial; they expect to enroll 175 in total.

Generic Brevibloc in Single-Dose Bags Now Available

By September 14, 2018

Esmolol Hydrochloride in Sodium Chloride Injection 2500mg/250 mL (10mg/mL) Single-Dose Plastic Bag and 2000mg/100mL (20mg/mL) Single-Dose Plastic Bag, a generic version of Brevibloc (Baxter) now available from Mylan.

New Apple Watch Includes ECG App, Irregular Heart Rhythm Notification Feature

By September 13, 2018

The irregular rhythm notification feature analyzes pulse rate data to identify episodes of irregular heart rhythms.

Bloodless Hyperkalemia Test Gets FDA's Breakthrough Device Designation

By September 12, 2018

The KardiaK Platform works through a deep neural network trained to detect hyperkalemia based on data from electrocardiograms (ECG) similar to those captured by the Company's KardiaMobile and KardiaBand devices.

Reducing HF Hospitalization Risk: Antidiabetic Drug Classes Compared

By September 11, 2018

The authors searched for randomized placebo-controlled trials (December 1, 2008 to November 24, 2017) involving 3 pharmacologic classes of antidiabetic medications to compare the effects of these agents on the risk of hospitalization for HF in T2DM patients.

Exposure to Toxic Metals May Up Cardiovascular Disease Risk

September 10, 2018

"These findings reinforce the importance of environmental toxic metals in cardiovascular risk, beyond the roles of conventional behavioral risk factors," the authors write.

Cardiovascular Health Risks Identified With Diclofenac Use

By September 07, 2018

To investigate the cardiovascular risks associated with diclofenac, researchers conducted a series of cohort studies mimicking the design criteria of a clinical trial.

An Allergy to Red Meat May Be Tied to Heart Disease

August 31, 2018

The researchers found that 26% of patients had antibodies to α-Gal, indicating sensitivity to red meat. The sensitized patients had significantly higher levels of arterial plaque (30% higher) vs non-sensitized patients.

VKA vs Non-VKA Oral Anticoagulants: Mortality Rates Compared in AF

By August 29, 2018

The new analysis included 19,134 of these patients and showed that there were 19% fewer deaths in patients initiated on NOACs compared to VKAs at the time of AF diagnosis.

High, Low Carbohydrate Diets Linked to Increased Mortality

August 29, 2018

The researchers found that there were 6,283 deaths in the ARIC cohort during a median follow-up of 25 years, and 40,181 deaths across all cohort studies (432,179 participants).

Labeling Mix-Up Prompts Recall of HCTZ Bottles That May Contain Another Diuretic

By August 29, 2018

To date, there have been no reports of any adverse events related to this recall.

Entresto Initiation Soon After Acute HF Episode Safe in HFrEF Patients

By August 27, 2018

The Phase 4, randomized, open-label, parallel-group TRANSITION study (N=1002) evaluated the safety and tolerability of Entresto in HFrEF patients after they were stabilized following an acute heart failure episode when treatment was initiated either pre-discharge or post-discharge.

Optimization of cardiovascular health metrics linked to better cerebrovascular structure and function

August 27, 2018

In this cross-sectional study, young adults with a greater number of modifiable cardiovascular (CV) risk factors at recommended levels was associated with higher cerebral vessel density and caliber and higher cerebral blood flow.

Plan to Relax Coal-Fired Power Plant Rules Could Up Mortality

August 22, 2018

It predicts between 470 and 1,400 premature deaths a year by 2030 because of increased levels of microscopic airborne particulates, which are linked with heart and lung disease and chronic problems like asthma and bronchitis, The Times reported.

Large Number of Presumed Sudden Cardiac Deaths Are Not

August 21, 2018

"These findings have implications for the accuracy of sudden cardiac deaths as defined by WHO criteria or emergency medical services records in aggregate mortality data, clinical trials, and cohort studies," the authors write.

Microtubules linked to cardiomyocyte function in heart failure

August 16, 2018

Post-translational detyrosination of microtubules results in resistance to cardiomyocyte sarcomere shortening and stretch.

Perspectives on USPSTF A-Fib Screening Recommendation

August 15, 2018

Physicians weigh in on the need to develop a screening strategy

Reduced incidence of MACE for at-risk patients adherent to Mediterranean diet

August 14, 2018

High risk cardiovascular patients adherent to a Mediterranean diet supplemented with nuts or extra virgin olive oil had a lower incidence of major cardiovascular events compared to patients advised to follow a reduced fat diet at a median follow-up of 4.8 years.

Review Addresses Nutritional Hype for Popular Foods

August 10, 2018

They found evidence of benefit for legumes, moderate habitual coffee consumption, tea, mushrooms, alcohol in recommended amounts, plant or marine omega-3 fatty acids, and vitamin B12 supplements for those who are deficient.

AHA: A Diverse Diet May Not Promote a Healthy Weight

August 10, 2018

The authors report that current data do not support greater dietary diversity as an effective strategy to promote healthy eating patterns and healthy body weight.

American Heart Association Urges Screen Time Limits for Youth

August 09, 2018

There is also a need to more accurately capture the nature of sedentary behavior, both quantitatively and qualitatively, especially with respect to recreational screen-based devices.

USPSTF: Insufficient Evidence to Screen for Atrial Fibrillation

August 09, 2018

There was inadequate evidence to determine whether screening with ECG and subsequent treatment in asymptomatic adults is more effective than usual care.

Which Opioids Are More Likely to Induce QT Interval Prolongation?

By August 07, 2018

Studies comparing MMT to buprenorphine maintenance treatment (BMT) over 5-years found buprenorphine to be a safer drug for opioid maintenance treatment as it had no significant effect on QT prolongation.

Kapspargo Sprinkle Available to Treat Hypertension, Angina, Heart Failure

By August 07, 2018

For patients unable to swallow an intact capsule, the pellets can be sprinkled over soft food (eg, applesauce, yogurt, pudding) or given via a nasogastric (NG) tube.

Ciprofloxacin May Up Likelihood of Aortic Dissection, Rupture

August 06, 2018

Increased susceptibility observed in mouse model of sporadic aortic aneurysm and dissection

AHA Introduces Heart Failure Certification Program

August 03, 2018

The certification program promotes heart failure management, including standard methods of delivering or coordinating care; implementation of evidence-based clinical practice guidelines; and use of a secure and timely system for sharing information that safeguards rights and privacy, among other things.