Topical Acne Treatments









TOPICAL ACNE TREATMENTS
Generic Brand Strength Form Dose
ANDROGEN RECEPTOR INHIBITOR
clascoterone Winlevi Rx 1% crm Adults: Apply thin layer to clean, dry affected area twice daily (AM and PM).
Children: <12yrs: Not established.
ANTIBACTERIAL/ANTIKERATINIZING
azelaic acid Azelex Rx 20% crm Adults: Gently massage thin film to affected areas twice daily (AM and PM) to clean, dry skin. Wash hands after use. May decrease to once daily if persistent irritation occurs.
Children: Not recommended.
ANTIBACTERIAL/KERATOLYTIC
benzoyl peroxide Rx 5%, 10% water-base gel Adults: Apply to cleansed area 1−2 times daily
Children: Not recommended.
wash Adults: Wash affected area 1−2 times daily; rinse
Children: Not recommended.
ANTIMICROBIALS
clinda
mycin
Cleocin T Rx 1% lotion, gel Adults: Apply thin film twice daily
Children: Not established.
Clindagel Rx 1% gel Adults: Apply thin film once daily
Children: Not recommended.
Clindets Rx 1% pledgets5 Adults: Apply thin film twice daily
Children: Not recommended.
Evoclin Rx 1% foam3 Adults: Apply once daily to clean, dry skin
Children: <12yrs: Not established.
erythro
mycin
Rx 2% gel Adults: Apply thin film 1−2 times daily
Children: Not established.
soln, pads3 Adults: Apply with applicator or pads to clean, dry skin twice daily
Children: Not recommended.
Ery 2% Pads Rx 2% pledgets3 Adults: Rub over cleansed area twice daily (AM & PM)
Children: Not applicable.
minocycline Amzeeq Rx 4% foam3 Adults and Children: <9yrs: Not established. ≥9yrs: Apply at the same time each day ≥1hr before bedtime. Rub gently into affected area(s); repeat as needed. Avoid bathing, showering or swimming for ≥1hr after application.
sodium sulfacet
amide
Klaron Rx 10% lotion Adults: Apply thin film twice daily to affected areas
Children: Not recommended.
KERATOLYTIC
salicylic acid Phisoderm
Anti-Blemish Body Wash
OTC 2% body wash Adults: Massage onto skin; rinse
Children: Not applicable.
Phisoderm
Anti-Blemish Gel Facial Wash
OTC 2% gel Adults: Massage onto skin twice daily; rinse
Children: Not applicable.
RETINOIDS
adapalene Differin Rx 0.1% crm6 Adults: Apply thin film to affected areas once daily after washing. Reduce frequency or discontinue if prolonged or severe irritation occurs.
Children: Not established.
OTC 0.1% gel6
Rx 0.3% gel6
0.1% lotion
tazarotene Arazlo Rx 0.045% lotion Adults and Children: <9yrs: Not established. ≥9yrs: Apply a thin film to affected areas once daily. Women of childbearing potential: begin therapy during normal menses.
Fabior Rx 0.1% foam Adults: Apply thin layer to clean, dry affected area (face, upper trunk) once daily in PM. Women of childbearing potential: Begin therapy during normal menses.
Children: Not recommended.
Tazorac Rx 0.05%*, 0.1% crm, gel Adults: Apply thin film of 0.1% strength to lesions on clean, dry face once daily in the PM. Women of childbearing potential: Begin therapy during normal menses.
Children: <12yrs: Not established.
tretinoin Altreno Rx 0.05% lotion4 Adults and Children: <9yrs: Not established. ≥9yrs: Apply thin layer to affected areas once daily. Reduce frequency or discontinue if severe irritation occurs.
Atralin Rx 0.05% gel2,4 Adults and Children: <10yrs: Not recommended. ≥10yrs: Apply sparingly at bedtime to clean skin once daily.
Adjust amount and frequency as tolerated.
Avita Rx 0.025% crm, gel Adults: Apply sparingly to clean, dry skin once daily at bedtime. If irritation develops, adjust dose or frequency as tolerated and needed.
Children: Not recommended.
Retin‑A Rx 0.025%, 0.05%, 0.1% crm
0.01%, 0.025% gel1
Retin‑A Micro Rx 0.04%, 0.08%, 0.1% aqueous gel
trifarotene Aklief Rx 0.005% crm Adults and Children: <9yrs: Not established. ≥9yrs: Apply a thin layer to affected areas once daily in the PM. Face: 1 pump actuation. Upper trunk: 2 pump actuations; may use 1 additional pump actuation for middle and lower back, if needed.
SULFONE
dapsone Aczone Rx 5% gel Adults: Apply pea-sized amount to affected area twice daily (AM & PM). Wash hands after use. Reevaluate if no improvement after 12wks.
Children: <12yrs: Not recommended.
7.5% gel Adults and Children: <9yrs: Not established. ≥9yrs: Apply pea-sized amount to affected area once daily. Wash hands after use. Reevaluate if no improvement after 12wks.
COMBINATION AGENTS
adapalene/ benzoyl peroxide Epiduo Forte Gel Rx 0.3%/
 
2.5%
gel Adults: Apply thin film to affected areas of face and/or trunk once daily after washing. Use a pea-sized amount for each area of the face. Reduce frequency or discontinue if prolonged or severe irritation occurs.
Children: <12yrs: Not established.
Epiduo Gel Rx 0.1%/
 
2.5%
gel Adults and Children: <9yrs: Not established. ≥9yrs: Apply thin film to clean affected areas (face, trunk) once daily. Use a pea-sized amount for each area of the face. Reduce frequency or discontinue if prolonged or severe irritation occurs.
clinda
mycin/ benzoyl peroxide
Acanya Rx 1.2%/
 
2.5%
gel Adults: Apply pea-sized amount in a thin layer to clean, dry face once daily. Wash hands after use.
Children: Not recommended.
Benzaclin Rx 1%/5% gel Adults: Apply twice daily
Children: Not recommended.
Duac Rx 1%/5% gel Adults: Apply to clean, dry skin once daily in the evening
Children: Not recommended.
Onexton Rx 1.2%/
 
3.75%
gel Adults: Apply a pea-sized amount once daily
Children: Not established.
erythro
mycin/
benzoyl peroxide
Benzamycin Rx 3%/5% gel Adults: Apply to clean, dry skin twice daily
Children: Not recommended.
tretinoin/
 
benzoyl peroxide
Twyneo Rx 0.1%/
 
3%
crm Adults and Children: <9yrs: Not established. ≥9yrs: Apply thin layer to clean, dry skin once daily.
clindamycin/ tretinoin Ziana Rx 1.2%/
 
0.025%
gel Adults: Apply thin film to clean, dry face once daily at bedtime
Children: Not recommended.
NOTES

*Only 0.1% indicated for mild to moderate acne vulgaris

1contains cetearyl alcohol
2contains parabens
3contains alcohol
4contains benzyl alcohol
5contains isopropyl alcohol
6alcohol‑free

Not an inclusive list of medications and/or doses. Please see drug monograph at www.eMPR.com, contact company for full drug labeling and/or consult your healthcare provider. Contains FDA‑approved doses only for Rx products.

(Rev. 1/2023)