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Hormone Replacement Therapies
| HORMONE REPLACEMENT THERAPIES | ||||
|---|---|---|---|---|
| Generic | Brand | Strength | Form | Dosing Frequency |
| ORAL ESTROGEN | ||||
| conjugated estrogens | Premarin | 0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg | tabs | Once daily |
| esterified estrogens | Menest | 0.3mg, 0.625mg, 1.25mg, 2.5mg | tabs | |
| estradiol (micronized) | Estrace | 0.5mg, 1mg, 2mg | tabs | |
| TRANSDERMAL ESTROGEN | ||||
| estradiol | Alora | 0.025mg/day, 0.05mg/day, 0.075mg/day, 0.1mg/day | transdermal system | Twice weekly |
| Climara | 0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.06mg/day, 0.075mg/day, 0.1mg/day | transdermal system | Once weekly | |
| Divigel | 0.25mg/pkt, 0.5mg/pkt, 0.75mg/pkt, 1mg/pkt, 1.25mg/pkt | topical gel | Once daily | |
| Elestrin | 0.87g/pump | topical gel | Once daily | |
| Estrogel | 1.25g/pump | topical gel | 1 pump once daily | |
| Evamist | 1.53mg/spray | transdermal spray | Initially 1 spray daily; may increase to 2−3 sprays if needed | |
| Menostar | 14mcg/day | transdermal system | Once weekly | |
| Minivelle | 0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.075mg/day, 0.1mg/day | trans– dermal system |
Twice weekly | |
| Vivelle-Dot | 0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.075mg/day, 0.1mg/day | transdermal system | Twice weekly | |
| VAGINAL ESTROGEN | ||||
| conjugated estrogens | Premarin | 0.625mg/g | cream | Once daily or twice weekly, cyclically* |
| estradiol | Estring | 7.5mcg/24hrs | ring | Once every 90 days |
| Femring | 0.05mg/day, 0.1mg/day | ring | Once every 3mos | |
| Imvexxy | 4mcg, 10mcg | vaginal inserts | Initially 4mcg once daily for 2wks, then twice weekly every 3–4 days | |
| Vagifem | 10mcg | vaginal inserts | Once daily for 2wks, then twice weekly | |
| ORAL ESTROGEN + ESTROGEN AGONIST/ANTAGONIST | ||||
| conjugated estrogens/ bazedoxifene |
Duavee | 0.45mg/20mg | tabs | Once daily |
| ORAL PROGESTOGEN | ||||
| medroxyprogesterone acetate | Provera | 2.5mg, 5mg, 10mg | tabs | Once daily |
| norethindrone acetate | — | 5mg | tabs | |
| progesterone (micronized) | Prometrium | 100mg, 200mg | caps | |
| ORAL ESTROGEN + PROGESTOGEN | ||||
| conjugated estrogens (14 tabs); then conjugated estrogens/ MPA (14 tabs) |
Premphase | 0.625mg; then 0.625mg/5mg | tabs | Once daily, sequentially |
| conjugated estrogens/ MPA (28 tabs) |
Prempro | 0.3mg/1.5mg, 0.45mg/1.5mg,
0.625mg/ 2.5mg, 0.625mg/5mg |
tabs | Once daily |
| estradiol/ drospirenone |
Angeliq | 0.5mg/0.25mg, 1mg/0.5mg | tabs | Once daily |
| estradiol/ norethindrone acetate |
Activella | 0.5mg/0.1mg, 1mg/0.5mg | tabs | Once daily |
| estradiol/ progesterone |
Bijuva | 0.5mg/100mg, 1mg/100mg | caps | Initially 0.5mg/100mg once daily in PM; adjust based on response |
| norethindrone acetate/ ethinyl estradiol |
— | 0.5mg/2.5mcg, 1mg/5mcg | tabs | Once daily Note: Progestin listed first |
| TRANSDERMAL ESTROGEN + PROGESTOGEN | ||||
| estradiol/ levonorgestrel |
Climara Pro | 0.045mg/ 0.015mg per day |
transdermal system | Once weekly |
| estradiol/ norethindrone acetate |
Combipatch | 0.05mg/ 0.14mg per day, 0.05mg/ 0.25mg per day |
transdermal system | Twice weekly |
| NOTES | ||||
|
*Once daily for atrophic vaginitis or kraurosis vulvae. Twice weekly for dyspareunia. Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. Estrogen component is listed first for combination products. Listed strengths are not necessarily the same as the dosage. Listed dosing frequency is for use in HRT; may be other frequencies for other uses. Some products are given cyclically. (Rev. 4/2022) |
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