Erectile Dysfunction Treatments
| ERECTILE DYSFUNCTION TREATMENTS | ||||||
|---|---|---|---|---|---|---|
| Generic | Brand | Form | Strength | Onset | Duration of Action |
Dosing Considerations |
| PDE-5 INHIBITORS | ||||||
| avanafil | Stendra | tabs | 50mg, 100mg, 200mg |
30− 45min (fasted state) |
5hrs |
• Initially 100mg 15min before sexual activity. • Max 200mg once daily. • Concomitant moderate CYP3A4 inhibitors: Max 50mg once every 24hrs. • Concomitant α-blockers: Initially 50mg. • Concomitant strong CYP3A4 inhibitors: Not recommended. |
| sildenafil | Viagra | tabs | 25mg, 50mg, 100mg |
0.5−2hrs (1hr) |
4hrs |
• Usually 25–100mg 1hr before sexual activity at frequency of up to once daily. • >65yrs old: Initially 25mg. • Severe renal dysfunction (CrCl<30mL/min): Initially 25mg. • Hepatic impairment: Initially 25mg. • Ketoconazole, itraconazole, erythromycin, saquinavir: Initially 25mg. • Ritonavir: Max 25mg every 48hrs. • α-blockers: Initially 25mg. |
| tadalafil | Cialis | tabs | 2.5mg, 5mg, 10mg, 20mg |
0.5−6hrs (2hrs) |
36hrs |
Use as Needed: • Usually 5–20mg before sexual activity at frequency of up to once daily. • >65yrs old: No adjustment needed. • Moderate renal dysfunction (CrCl 30−50mL/min): Initially 5mg; max 10mg/48hrs. • Severe renal dysfunction (CrCl<30mL/min): Max 5mg/72hrs. • Mild or moderate hepatic impairment: Max 10mg daily; severe: Not recommended. • Ketoconazole, ritonavir: Max 10mg every 72hrs. • α-blockers: Lowest recommended dose. |
| see full labeling |
Once−Daily Use: • Initially 2.5mg (taken at same time each day); may increase to 5mg/day. • Severe renal dysfunction (CrCl<30mL/min): Not recommended. • Mild or moderate hepatic impairment: Use caution; severe: Not recommended. • Concomitant potent CYP3A4 inhibitors: Max 2.5mg. • For ED + BPH: 5mg taken at same time once daily without regard to timing of sexual activity. |
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| varden– afil |
Levitra | tabs | 5mg, 10mg, 20mg |
0.5−2hrs (1hr) |
4hrs |
• Initially 10mg 1hr before sexual activity; usual range: 5−20mg once daily as needed. • ≥65yrs old: Initially 5mg. • Moderate hepatic impairment: initially 5mg; max 10mg. • Concomitant ketoconazole or itraconazole 200mg/day, or erythromycin: max 5mg. Concomitant ketoconazole or itraconazole 400mg/day, clarithromycin, saquinavir, atazanavir or indinavir: max 2.5mg. Concomitant ritonavir: max 2.5mg/72hrs. • Concomitant α-blocker: initially 5mg/day. • Severe hepatic impairment, hemodialysis: Not recommended. |
| Staxyn | orally disinte– grating tabs |
10mg | 0.75− 2.5hrs (1.5hr) |
4−6hrs |
• Take as needed approximately 60min before sexual activity; max: 10mg/day. • Not interchangeable with Levitra 10mg. • Do not take with water. Place on tongue to disintegrate. • Moderate to severe hepatic impairment or renal dialysis: Not recommended. • Concomitant α-blockers: use lower doses of vardenafil film-coated tabs as initial therapy. |
|
| PROSTAGLANDIN E1 | ||||||
| alpros– tadil |
Caverject | injection, intraca– vernous |
20mcg, 40mcg |
5−20min | 1hr |
• Usually 1.25−60mcg within 1hr before anticipated sexual activity. • Max 3 inj/wk with a 24‑hr period between each injection. |
| Edex | injection, intraca– vernous |
10mcg, 20mcg, 40mcg |
5–20min | 1hr |
• Usually 1−40mcg within 1hr before anticipated sexual activity. • Max of 3 inj/wk with a 24‑hr period between each injection. |
|
| Muse | supposi– tory, urethral |
125mcg, 250mcg, 500mcg, 1000mcg |
5−10min | 0.5−1hr |
• Initially 125−250mcg. • Max 2 systems/24hrs. |
|
| Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling.
(Rev. 2/2021) |
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