Erectile Dysfunction Treatments

ERECTILE DYSFUNCTION TREATMENTS
Generic Brand Strength Form Onset Half-life Dosing Considerations
PDE-5 INHIBITORS
avanafil Stendra 50mg,
100mg,
200mg
tabs 15–30mins 5hrs

• Initially 100mg 15min before sexual activity.

• May reduce to 50mg taken approx. 30mins before activity or increase to 200mg taken approx. 15mins before activity. Take no more than once daily.

Concomitant moderate CYP3A4 inhibitors: Max 50mg once every 24hrs.

Concomitant α-blockers: Initially 50mg.

Concomitant strong CYP3A4 inhibitors: Not recommended.

sildenafil Viagra 25mg,
50mg,
100mg
tabs 0.5–4hrs (1hr) 4hrs

• Initially 50mg 1hr (30mins–4hrs) before sexual activity. May reduce to 25mg or increase to max of 100mg. Take no more than once daily.

Elderly, hepatic impairment, severe renal impairment, or concomitant strong CYP3A4 inhibitors: consider initial dose of 25mg.

Ritonavir: Max 25mg every 48hrs.

α-blockers: Initially 25mg.

tadalafil Cialis 2.5mg,
5mg,
10mg,
20mg
tabs 30mins ≤36hrs

Use as Needed:

• Initially 10mg before sexual activity; range: 5–20mg. Take no more than once daily.

Renal impairment: CrCl 30–50mL/min: initially 5mg/day; max 10mg/48hrs; CrCl <30mL/min or hemodialysis: max 5mg/72hrs.

Mild to moderate hepatic impairment: max 10mg/day.

Concomitant potent CYP3A4 inhibitors: max 10mg/72hrs.

Concomitant α-blockers: use lowest recommended dose.

see full labeling

Once−Daily Use:

• Initially 2.5mg (taken at same time each day); may increase to 5mg/day.

Concomitant potent CYP3A4 inhibitors: max 2.5mg.

CrCl<30mL/min or hemodialysis: not recommended.

Concomitant α-blockers: use lowest recommended dose.

For ED + BPH: 5mg taken at same time once daily without regard to timing of sexual activity.

varden
afil
2.5mg, 5mg, 10mg, 20mg tabs 1hr 4hrs

• Initially 10mg 1hr before sexual activity; usual range: 5−20mg once daily as needed. Take no more than once daily.

≥65yrs old: Initially 5mg.

Moderate hepatic impairment: initially 5mg; max 10mg.

Concomitant ketoconazole or itraconazole 200mg/day, or erythromycin: max 5mg. Concomitant ketoconazole or itraconazole 400mg/day, clarithromycin, saquinavir, atazanavir or indinavir: max 2.5mg. Concomitant ritonavir: max 2.5mg/72hrs.

Concomitant α-blocker: initially 5mg/day.

Severe hepatic impairment, hemodialysis: Not recommended.

10mg orally disinte
grating tabs
1hr 4−6hrs

• Place one tab on tongue, approx. 1hr before sexual activity; max 1 tab/day. Take without liquid.

• Not interchangeable with vardenafil 10mg film-coated tabs.

Concomitant moderate or potent CYP3A4 inhibitors: not recommended.

Moderate to severe hepatic impairment or renal dialysis: Not recommended.

Concomitant α-blockers: use lower doses of vardenafil film-coated tabs as initial therapy.

PROSTAGLANDIN E1
alpros
tadil
Caverject 20mcg,
40mcg
injection, intraca
vernous
5−20min 1hr

• Usually 1.25−60mcg within 1hr before anticipated sexual activity.

• Max 3 inj/wk with a 24‑hr period between each injection.

Edex 10mcg,
20mcg,
40mcg
injection, intraca
vernous
5–20min 1hr

• Usually 1−40mcg within 1hr before anticipated sexual activity.

• Max of 3 inj/wk with a 24‑hr period between each injection.

Muse 125mcg,
250mcg,
500mcg,
1000mcg
supposi
tory, urethral
5−10min 0.5−1hr

• Initially 125−250mcg.

• Max 2 systems/24hrs.

Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling.

(Rev. 10/2022)