Erectile Dysfunction Treatments
| ERECTILE DYSFUNCTION TREATMENTS | ||||||
|---|---|---|---|---|---|---|
| Generic | Brand | Strength | Form | Onset | Half-life | Dosing Considerations |
| PDE-5 INHIBITORS | ||||||
| avanafil | Stendra | 50mg, 100mg, 200mg |
tabs | 15–30mins | 5hrs |
• Initially 100mg 15min before sexual activity. • May reduce to 50mg taken approx. 30mins before activity or increase to 200mg taken approx. 15mins before activity. Take no more than once daily. • Concomitant moderate CYP3A4 inhibitors: Max 50mg once every 24hrs. • Concomitant α-blockers: Initially 50mg. • Concomitant strong CYP3A4 inhibitors: Not recommended. |
| sildenafil | Viagra | 25mg, 50mg, 100mg |
tabs | 0.5–4hrs (1hr) | 4hrs |
• Initially 50mg 1hr (30mins–4hrs) before sexual activity. May reduce to 25mg or increase to max of 100mg. Take no more than once daily. • Elderly, hepatic impairment, severe renal impairment, or concomitant strong CYP3A4 inhibitors: consider initial dose of 25mg. • Ritonavir: Max 25mg every 48hrs. • α-blockers: Initially 25mg. |
| tadalafil | Cialis | 2.5mg, 5mg, 10mg, 20mg |
tabs | 30mins | ≤36hrs |
Use as Needed: • Initially 10mg before sexual activity; range: 5–20mg. Take no more than once daily. • Renal impairment: CrCl 30–50mL/min: initially 5mg/day; max 10mg/48hrs; CrCl <30mL/min or hemodialysis: max 5mg/72hrs. • Mild to moderate hepatic impairment: max 10mg/day. • Concomitant potent CYP3A4 inhibitors: max 10mg/72hrs. • Concomitant α-blockers: use lowest recommended dose. |
| see full labeling |
Once−Daily Use: • Initially 2.5mg (taken at same time each day); may increase to 5mg/day. • Concomitant potent CYP3A4 inhibitors: max 2.5mg. • CrCl<30mL/min or hemodialysis: not recommended. • Concomitant α-blockers: use lowest recommended dose. • For ED + BPH: 5mg taken at same time once daily without regard to timing of sexual activity. |
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| varden– afil |
— | 2.5mg, 5mg, 10mg, 20mg | tabs | 1hr | 4hrs |
• Initially 10mg 1hr before sexual activity; usual range: 5−20mg once daily as needed. Take no more than once daily. • ≥65yrs old: Initially 5mg. • Moderate hepatic impairment: initially 5mg; max 10mg. • Concomitant ketoconazole or itraconazole 200mg/day, or erythromycin: max 5mg. Concomitant ketoconazole or itraconazole 400mg/day, clarithromycin, saquinavir, atazanavir or indinavir: max 2.5mg. Concomitant ritonavir: max 2.5mg/72hrs. • Concomitant α-blocker: initially 5mg/day. • Severe hepatic impairment, hemodialysis: Not recommended. |
| — | 10mg | orally disinte– grating tabs |
1hr | 4−6hrs |
• Place one tab on tongue, approx. 1hr before sexual activity; max 1 tab/day. Take without liquid. • Not interchangeable with vardenafil 10mg film-coated tabs. • Concomitant moderate or potent CYP3A4 inhibitors: not recommended. • Moderate to severe hepatic impairment or renal dialysis: Not recommended. • Concomitant α-blockers: use lower doses of vardenafil film-coated tabs as initial therapy. |
|
| PROSTAGLANDIN E1 | ||||||
| alpros– tadil |
Caverject | 20mcg, 40mcg |
injection, intraca– vernous |
5−20min | 1hr |
• Usually 1.25−60mcg within 1hr before anticipated sexual activity. • Max 3 inj/wk with a 24‑hr period between each injection. |
| Edex | 10mcg, 20mcg, 40mcg |
injection, intraca– vernous |
5–20min | 1hr |
• Usually 1−40mcg within 1hr before anticipated sexual activity. • Max of 3 inj/wk with a 24‑hr period between each injection. |
|
| Muse | 125mcg, 250mcg, 500mcg, 1000mcg |
supposi– tory, urethral |
5−10min | 0.5−1hr |
• Initially 125−250mcg. • Max 2 systems/24hrs. |
|
| Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling.
(Rev. 10/2022) |
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