COPD Treatments
COPD TREATMENTS
Generic Brand Form Usual Dosage
BRONCHODILATORS
Long-Acting Beta2‑Agonists (LABAs)
arformoterol Brovana* soln Adults: Inhale 15mcg twice daily (AM & PM) by
nebulization (max: 30mcg/day). Use standard jet
nebulizer with air compressor (see full labeling).
Children: Not established.
formoterol Perforomist* soln Adults: Inhale one 20mcg vial twice daily (AM & PM) by nebulization (max: 40mcg/day). Use standard jet nebulizer and air compressor.
Children: Not established.
olodaterol Striverdi Respimat* MDI Adults: 2 inh once daily; max 2 inh/24hrs
Children: Not established.
salmeterol Serevent Diskus* DPI Adults: 1 inh (50mcg) twice daily (approx. 12hrs apart)
Children: Not established.
Short-Acting Anticholinergics
ipratropium bromide soln Adults: 500mcg by oral nebulization 3−4 times
daily every 6−8hrs
Children: Not established.
Atrovent HFA MDI Adults: 2 inh 4 times daily; max 12 inh/24hrs
Children: Not established.
Long-Acting Anticholinergics
aclidinium bromide Tudorza Pressair DPI Adults: 1 inh (400mcg) twice daily (approx. 12hrs apart)
Children: Not established.
glycopyrrolate Lonhala Magnair* soln Adults: 1 oral inh of one 25mcg vial twice daily (AM & PM); max 2 inh/24hrs. Only use with Magnair device.
Children: Not established.
revefenacin Yupelri* soln Adults: 1 oral inh of one 175mcg vial once daily using a mouthpiece. Use standard jet nebulizer with air compressor.
Children: Not established.
tiotropium bromide Spiriva HandiHaler caps Adults: 2 inh of one 18mcg cap once daily, using HandiHaler device. Max: 2 inh/24hrs.
Children: Not established.
Spiriva Respimat MDI Adults: 2 inh of 2.5mcg/actuation (5mcg) once daily; max: 2 inh/24hrs
Children: Not established.
umeclidinium Incruse Ellipta* DPI Adults: 1 inh once daily; max 1 inh/24hrs
Children: Not established.
Anticholinergic + Beta2‑Agonist
ipratropium bromide + albuterol soln Adults: 1 vial 4−6 times daily via nebulizer
Children: Not established.
Combivent 
Respimat
MDI Adults: 1 inh 4 times daily; max 6 inh/24hrs
Children: Not established.
Anticholinergic + Long-Acting Beta2‑Agonist (LABA)
aclidinium bromide/ formoterol Duaklir Pressair* DPI Adults: 1 inh twice daily (AM & PM); max 1 inh twice daily
Children: Not established.
glycopyrrolate + formoterol Bevespi Aerosphere* MDI Adults: 2 inh twice daily (AM & PM); max 2 inh twice daily 
Children: Not established.
tiotropium + olodaterol Stiolto Respimat* MDI Adults: 2 inh once daily; max 2 inh/24hrs
Children: Not established.
umeclidinium + vilanterol Anoro Ellipta* DPI Adults: 1 inh once daily; max 1 inh/24hrs
Children: Not established.
CORTICOSTEROIDS
Corticosteroid + Long-Acting Beta2-Agonist (LABA)
budesonide + formoterol Symbicort 160/4.5* MDI Adults: 2 inh of 160/4.5mcg twice daily (approx. 12hrs apart)
Children: Not indicated.
fluticasone propionate + salmeterol Advair 250/50 Diskus* DPI Adults: 1 inh of 250/50mcg twice daily (approx. 12hrs apart)
Children: Not established.
Wixela Inhub* DPI Adults: 1 inh of 250/50mcg twice daily (approx. 12hrs apart)
Children: Not established.
fluticasone furoate + vilanterol Breo Ellipta* DPI Adults: 1 inh of 100/25mcg once daily; max 1 inh/24hrs
Children: Not established.
Corticosteroid + Anticholinergic + Long-Acting Beta2-Agonist (LABA)
budesonide + glycopyrrolate + formoterol Breztri Aerosphere* MDI Adults: 2 inh twice daily (AM & PM); max 2 inh twice daily
Children: Not established.
fluticasone furoate + umeclidinium + vilanterol Trelegy Ellipta* DPI Adults: 1 inh of 100/62.5/25mcg once daily; max 1 inh/24hrs
Children: Not established.
OTHER
PDE4-Inhibitor
roflumilast Daliresp tabs Adults: 500mcg once daily. Initiating 250mcg daily for 4wks, then increasing to 500mcg may reduce the rate of discontinuation in some patients. 
Children: Not established.
NOTES

Key: DPI = dry powder inhaler; MDI = metered dose inhaler

*Not indicated to treat acute deteriorations of COPD.

Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling.

(Rev. 12/2022)