|BLEEDING DISORDER TREATMENTS: VON WILLEBRAND DISEASE|
|ANTIHEMOPHILIC FACTOR VIII/VON WILLEBRAND FACTOR COMPLEX|
|Alphanate1||250 IU, 500 IU, 1000 IU, 1500 IU, 2000 IU||lyophilized pwd for IV inj after reconstitution||Adults: Pre-op: 60 VWF:RCo IU/kg, then 40–60 VWF:RCo IU/kg every 8–12hrs if needed; may reduce dose after 3rd post-op day; treat until healed. Max infusion rate ≤10mL/min.
Children: Initially 75 VWF:RCo IU/kg, then 50–75 VWF:RCo IU/kg every 8–12hrs if needed; may reduce dose after 3rd post-op day; treat until healed. Max infusion rate ≤10mL/min.
|Humate-P||250 IU FVIII + 600 IU VWF, 500 IU FVIII + 1200 IU VWF, 1000 IU FVIII + 2400 IU VWF||lyophilized pwd for IV infusion after reconstitution||Adults and Children: Type 1 (Mild): major bleed: initially 40–60 IU/kg, then 40–50 IU/kg every 8–12hrs for 3 days, then once daily for a total of 7 days. Type 1 (Moderate or severe): minor bleed: 40–50 IU/kg for 1–2 doses; major bleed: initially 50–75 IU/kg, then 40–60 IU/kg every 8–12hrs for 3 days, then once daily for a total of 7 days. Types 2 and 3: minor bleed: 40–50 IU/kg for 1–2 doses; major bleed: initially 60–80 IU/kg, then 40–60 IU/kg every 8–12hrs for 3 days, then once daily for a total of 7 days. Max infusion rate: 4mL/min. Surgery: see full labeling.|
|Wilate||500 IU FVIII + 500 IU VWF:RCo, 1000 IU FVIII + 1000 IU VWF:RCo||pwd for IV inj after reconstitution||<5yrs: Contact manufacturer. ≥5yrs: Minor bleed: 20–40 IU/kg once, then 20–30 IU/kg every 12–24hrs as needed. Major bleed: 40–60 IU/kg once, then 20–40 IU/kg every 12–24hrs as needed. Surgery (give loading dose within 3hrs before); Minor: 30–60 IU/kg once, then 15–30 IU/kg (or half the loading dose) every 12–24hrs; Major: 40–60 IU/kg once, then 20–40 IU/kg (or half the loading dose) every 12–24hrs. Usual duration: minor hemorrhage/surgery: 3 days; major hemorrhage: 5–7 days; major surgery: ≥6 days.|
|Stimate2||150mcg/spray||soln for nasal spray||Adults and Children: <11mos: not recommended.Give test dose prior to initiation. >11mos: <50kg: 1 spray in one nostril (150mcg). ≥50kg: 1 spray per nostril (300mcg). May repeat dose based on clinical response. Pre-op: give 2hrs prior to procedure.|
|VON WILLEBRAND FACTOR|
|Vonvendi3||650 IU VWF:RCo, 1300 IU VWF:RCo||lyophilized pwd for IV inj after reconstitution||Adults: ≥18yrs: Minor bleed: initially 40–50 IU/kg, then every 8–24hrs as needed. Major bleed: initially 50–80 IU/kg, then 40–60 IU/kg every 8–24hrs for 2–3 days as needed. Routine prophylaxis: initially 40–60 IU/kg twice weekly; adjust dose up to 60 IU/kg twice weekly if breakthrough bleeding occurs in joints or if severe bleeding occurs. Surgery: see full labeling. Max infusion rate: 4mL/min.
Children: <18yrs: not established.
Key: FVIII = Factor VIII; VWF = von Willebrand factor; VWF:RCo = von Willebrand factor Ristocetin cofactor
1 Not for severe VWD (Type 3) undergoing major surgery.
2 For mild-moderate Type 1 VWD with Factor VIII >5% only.
3 Give recombinant FVIII with first infusion if baseline plasma FVIII level <40% or is unknown. Recombinant FVIII may also be needed for subsequent infusions or prior to surgery.
Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling.
Bleeding Disorder Treatments: von Willebrand Disease