|Detection of fever varies based on the site of body measurement.|
|Generic||Form||Strengths||Children’s Dose||Adult Dose|
|Rx||injection||10mg/mL|| 0–28days: 12.5mg/kg every 6hrs; max: 50mg/kg/24hrs. Minimum dosing interval: 6hrs.
29days–2yrs: 15mg/kg every 6hrs; max: 60mg/kg/24hrs. Minimum dosing interval: 6hrs.
≥2yrs: 15mg/kg every 6hrs (or 12.5mg/kg every 4hrs); max single dose: 15mg/kg (up to 750mg), max daily dose: 75mg/kg/24hrs (up to 3750mg). Minimum dosing interval: 4hrs.
| <50kg: Same as children’s (≥2yrs) dose.
≥50kg: 1000mg every 6hrs (or 650mg every 4hrs); max single dose: 1000mg, max daily dose: 4000mg/24hrs. Minimum dosing interval: 4hrs.
|OTC||tabs||325mg, 500mg|| 10−15mg/kg every 4−6hrs
Max: <12yrs: 2.6g/day
| Regular strength immediate-release: 650mg every 4–6hrs
Extra strength immediate-release: 1000mg every 6hrs
Ext-rel: ≥12yrs: 2 tabs every 8hrs
|80mg, 120mg, 325mg, 650mg|
|aspirin||OTC||tabs||81mg, 325mg, 500mg||≤15yrs: Not recommended3|| Oral: 325−650mg every 4−6hrs
Rectal: 300−600mg every 4−6hrs
|del‑rel tabs||81mg, 325mg, 500mg, 650mg|
|60mg, 120mg, 200mg, 300mg, 600mg|
|ibuprofen||Rx||injection||100mg/mL|| <6mos: Not established.
≥6mos–<12yrs: 10mg/kg up to max single dose of 400mg every 4–6hrs as needed. Max: 40mg/kg or 2.4g/day
12–17yrs: 400mg every 4–6hrs as needed. Max: 2.4g/day
| Initially 400mg, then 400mg every 4−6hrs or 100−200mg every 4hrs
|OTC||tabs||100mg, 200mg|| 6mos−12yrs:
<102.5°F (<39°C): 5mg/kg/dose;
>102.5°F (>39°C): 10mg/kg/dose every 6−8hrs
| 200−400mg every 4−6hrs
|100mg/5mL, 40mg/mL, 50mg/
|naproxen||OTC||tabs||220mg||<12yrs: Consult physician.||220mg every 8–12hrs (may give 440mg as 1st dose initially). Max: 660mg/24hrs. Elderly: max 220mg every 12hrs.|
1Max dose is 3250mg/day for Tylenol brand regular strength and 3g/day for Tylenol brand extra strength; dosing interval for Tylenol brand extra strength is every 6hrs.
2Max dose is 2g/day for patients with poor nutritional intake, those taking concurrent hepatotoxic medications, or those who drink three or more alcoholic beverages daily.
3Aspirin may be given to children ≤15yrs of age under physician supervision if influenza or chickenpox can be confidently ruled out (10−15mg/kg every 4−6hrs, max 5 doses/24hrs).
Adapted from: Feret BM. Chapter 6. Fever. In: Krinsky DL, Berardi RR, Ferreri SP, et al, eds. Handbook of Nonprescription Drugs: An Interactive Approach to Self‑Care, 20th Edition. Washington, DC: American Pharmacists Association; 2020.
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