Carisoprodol/Aspirin/Codeine CIII

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Musculoskeletal pain
Only 4 drugs may be compared at once

Generic Name and Formulations:

Carisoprodol 200mg, aspirin 325mg, codeine phosphate 16mg; tabs; contains sulfites.

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Indications for Carisoprodol/Aspirin/Codeine:

Relief of painful musculoskeletal conditions.


1–2 tabs 4 times daily. May treat up to 2–3 weeks.


<16yrs: not established.


GI complication (eg, bleeding, perforation, obstruction) due to aspirin use. Aspirin-induced asthma. Carbamate sensitivity. NSAID allergy. Porphyria. Post-op pain management in children who have undergone tonsillectomy and/or adenoidectomy.


Risk of respiratory depression and death related to ultra-rapid metabolizers of codeine (esp. children in post-op tonsillectomy and/or adenoidectomy). Peptic ulcer. Gastritis. Acute abdominal conditions. Pancreatic or biliary duct disease. Renal or hepatic dysfunction. History of drug abuse. Asthma. COPD. Lung disease. Increased intracranial pressure. Dehydration. Use lowest effective dose for shortest duration. Elderly. Debilitated. Pregnancy (Cat.D). Nursing mothers: not recommended.

Pharmacological Class:

Muscle relaxant (central) + salicylate + opioid.


Additive effects with alcohol, CNS depressants, oral anticoagulants, hypoglycemics and plasma bound drugs (eg, methotrexate); use caution. Alcohol, NSAIDs, and oral anticoagulants increase risk of GI bleeding. May reduce antihypertensive effects with concomitant ACEIs, ARBs, beta-blockers, diuretics. Uricosurics antagonized. Urine alkalinizers or acidifiers decrease or increase, respectively, aspirin levels.

Adverse Reactions:

Dizziness, drowsiness, vertigo, ataxia, GI upset or bleeding, epigastric discomfort, tachycardia, orthostatic hypotension, facial flushing, rash, tinnitus; respiratory depression, hypotension.


Formerly known under the brand name Soma Compound w. Codeine.

How Supplied:

Contact supplier.