Bacterial Infections

Prevnar 13 Linked to Reduced Risk of CAP Hospitalization in Older Patients

By May 24, 2018

PCV13, marketed as Prevnar 13, was evaluated in a test-negative case-control study in real-world conditions where patients were administered pneumococcal vaccination as advised by their healthcare providers.

FDA to Review Aemcolo for Treatment of Travelers' Diarrhea

By May 23, 2018

A Phase 3 clinical trial of patients with travelers' diarrhea demonstrated that Aemcolo was superior to placebo (P=.0008) and non-inferior to ciprofloxacin.

Procalcitonin Assay Doesn't Cut Antibiotic Use in Lower RTI

May 23, 2018

Provision of assay doesn't result in less antibiotic use for suspected lower respiratory tract infection

Positive Results Announced for Pleuromutilin Antibiotic in CABP

By May 22, 2018

In the LEAP 2 study (N=738), patients with moderate CABP received either oral lefamulin 600mg every 12 hours for 5 days or oral moxifloxacin 400mg once daily for 7 days

Mecillinam/Pivmecillinam Get QIDP Designation for Complicated UTI

By May 21, 2018

Mecillinam is a beta-lactam antibiotic with a novel site of action which is specific and highly active against Gram-negative bacteria.

IV Combo Antibiotic Recalled Due to Potential for Decreased Potency

By May 15, 2018

The 36 recalled lots were manufactured by Hospira and marketed by Apotex.

<i>B. cepacia</i> Outbreak Tied to No-Rinse Cleansing Foam

By May 11, 2018

As a result of the tests, the FDA is advising consumers and clinicians to avoid using all lots of Remedy Essentials No-Rinse Cleansing Foam.

FDA Panel Votes on Plazomicin for Complicated UTI, Bloodstream Infections

By May 03, 2018

The Committee voted unanimously (15-0) that substantial evidence on the safety and efficacy of plazomicin was presented for the treatment of cUTI but voted against its use (4-11) for the treatment of bloodstream infections in patients with limited or no treatment options.

Drug-Related Endocarditis Cases Up From 2007 to 2015

April 27, 2018

Most cases were insured by federal and/or state programs (73.6 and 10.1%, respectively), but many (44.9%) patients were considered under-insured. In 2015, hospital charges of $4,580,786.88 were identified for the 66 cases of illicit drug-associated endocarditis.

MenB Vaccine Gets Breakthrough Tx Designation for Kids Ages 1 to 9 Years

By April 23, 2018

The Breakthrough designation was based on data from Phase 2 studies which assessed the safety and efficacy of the vaccine in this patient population.

Prediction tool for urinary tract infections in preverbal children

April 23, 2018

The study reports the development of a clinical and biochemical prediction tool for assessing the risk of urinary tract infection in preverbal children with fever. The model developed accurately predicted which patients may need further testing based on clinical variables, and who may need antibiotics therapy based on urine analysis supplement.

<i>C. Difficile</i> Risk Higher With Stoma Reversal vs Difficile

April 18, 2018

Factors associated with C. difficile infection incidence in the 30-day postoperative period after controlling for other variables include stoma reversal (odds ratio, 2.701; P<.001), smoking (odds ratio, 1.520; P<.022), steroids (odds ratio, 1.677; P<.048), and disseminated cancer.

Review: Treatment Recommendations for Biological Disasters

By April 17, 2018

The Centers for Disease Control and Prevention (CDC) classifies key biological agents into three categories: A, B, and C.

It Costs &#36;2.2 Billion a Year to Treat Antibiotic Resistance

April 16, 2018

Antibiotic resistance adds 1,383 to the cost of treating a bacterial infection

Pharmacists Play Role in Cutting Hospital-Acquired Infections

April 10, 2018

Pharmacists are increasingly becoming involved in antibiotic surveillance, formulation of policies relating to use of antibiotics, and control of problematic antibiotic use.

Large Drop Seen in Infection-Related Post-Transplant Deaths

April 06, 2018

Infectious causes of death and mortality rates for infections for 2 time periods - 1990 to 1999 and 2000 to 2012 - among 3,249 adult recipients of a first kidney transplant were assessed during the study period.

Omadacycline Granted Priority Review for CABP, Skin/Skin Structure Infections

By April 05, 2018

Omadacycline is an investigational, once-daily, broad-spectrum aminomethylcycline antibiotic that is related to tetracyclines.

CDC: Aggressive Action Needed to Contain Antibiotic Resistance

April 04, 2018

In screening tests, 11% of non-symptomatic individuals had a hard-to-treat bacteria that spreads easily; 25% of the bacteria tested had genes that allow them to spread their resistance.

FDA Issues Mandatory Recall of Food Products Containing Powdered Kratom

By April 03, 2018

The recall is due to samples of the product testing positive for Salmonella.

"Condom Challenge" Growing in Popularity Among Teens

By April 03, 2018

"As graphic as it is, we have to show parents because teens are going online looking for challenges and recreating them," said education specialist Stephen Enriquez.

Firvanq Availability Replaces Need for Compounded Oral Vancomycin Solution

By April 02, 2018

Firvanq will replace CutisPharma's FIRST-Vancomycin Unit-of-Use Compounding Kit.

NDA for Novel Amikacin Inhalation Submitted for Rare Lung Infection

By March 29, 2018

ALIS has previously been designated orphan drug status, breakthrough therapy status and a Qualified Infectious Disease Product.

Antibiotic Treatment Duration for Sinusitis Often Exceeds Recommendations

By March 28, 2018

Duration of outpatient antibiotic therapy for acute sinusitis often exceeds guidelines recommendations.

Decrease in U.S. Mortality From Infectious Diseases Seen in Last 3 Decades

March 28, 2018

A total of 113,650 deaths or a rate of 34.10 per 100,000 persons were due to infectious diseases in the United States in 2014, compared with 72,220 deaths or a rate of 41.95 deaths per 100,000 persons in 1980.

Long-Term Effects of Eradicating <i>H. Pylori</i> Examined for Gastric Cancer Risk

March 22, 2018

For the 327 patients who underwent histologic analysis, improvement in the atrophy grade at the gastric corpus lesser curvature from baseline was observed in 48.4% of the patients in the treatment group and in 15% of those in the placebo group.

Flucytosine plus fluconazole is noninferior to amphotericin B in treating cryptococcal meningitis

March 20, 2018

Treatment of cryptococcal meningitis with two weeks of flucytosine and fluconazole was noninferior to two weeks of amphotericin B.

Providers Trained in Integrative Medicine Less Likely to Prescribe Antibiotics

March 20, 2018

However, significantly fewer total antibiotics (relative risk [RR], 0.78) and antibiotics for respiratory tract infection (RR, 0.74) were prescribed for integrative medicine GP surgeries versus conventional GP surgeries.

Have Recent Guidelines Reduced Inappropriate Antibiotic Prescribing?

March 19, 2018

The researchers found that during the 3-year study period, about 98 million outpatient antibiotic prescriptions were filled by 39 million insurance beneficiaries. Azithromycin, amoxicillin, amoxicillin/clavulanate, ciprofloxacin, and cephalexin were the most commonly prescribed antibiotics.

Does Gut Bacteria Translocate to the Brain During Sepsis?

March 15, 2018

Among humans who died of sepsis, bacterial taxa detected in their brains were distinct from those who died of noninfectious causes and were correlated with S100A8/A9 expression.

Pediatric Appendicitis Risk Calculator Shows Promising Accuracy Results

March 15, 2018

The researchers included sex, age, duration of pain, guarding, pain migration, maximal tenderness in the right-lower quadrant, and absolute neutrophil count in the final pARC model. The pARC showed near perfect calibration in the validation sample as well as a high degree of discrimination (area under the curve, 0.85).