PCV13, marketed as Prevnar 13, was evaluated in a test-negative case-control study in real-world conditions where patients were administered pneumococcal vaccination as advised by their healthcare providers.
A Phase 3 clinical trial of patients with travelers' diarrhea demonstrated that Aemcolo was superior to placebo (P=.0008) and non-inferior to ciprofloxacin.
In the LEAP 2 study (N=738), patients with moderate CABP received either oral lefamulin 600mg every 12 hours for 5 days or oral moxifloxacin 400mg once daily for 7 days
Mecillinam is a beta-lactam antibiotic with a novel site of action which is specific and highly active against Gram-negative bacteria.
As a result of the tests, the FDA is advising consumers and clinicians to avoid using all lots of Remedy Essentials No-Rinse Cleansing Foam.
The Committee voted unanimously (15-0) that substantial evidence on the safety and efficacy of plazomicin was presented for the treatment of cUTI but voted against its use (4-11) for the treatment of bloodstream infections in patients with limited or no treatment options.
Most cases were insured by federal and/or state programs (73.6 and 10.1%, respectively), but many (44.9%) patients were considered under-insured. In 2015, hospital charges of $4,580,786.88 were identified for the 66 cases of illicit drug-associated endocarditis.
The Breakthrough designation was based on data from Phase 2 studies which assessed the safety and efficacy of the vaccine in this patient population.
The study reports the development of a clinical and biochemical prediction tool for assessing the risk of urinary tract infection in preverbal children with fever. The model developed accurately predicted which patients may need further testing based on clinical variables, and who may need antibiotics therapy based on urine analysis supplement.
Factors associated with C. difficile infection incidence in the 30-day postoperative period after controlling for other variables include stoma reversal (odds ratio, 2.701; P<.001), smoking (odds ratio, 1.520; P<.022), steroids (odds ratio, 1.677; P<.048), and disseminated cancer.
Pharmacists are increasingly becoming involved in antibiotic surveillance, formulation of policies relating to use of antibiotics, and control of problematic antibiotic use.
Infectious causes of death and mortality rates for infections for 2 time periods - 1990 to 1999 and 2000 to 2012 - among 3,249 adult recipients of a first kidney transplant were assessed during the study period.
Omadacycline is an investigational, once-daily, broad-spectrum aminomethylcycline antibiotic that is related to tetracyclines.
In screening tests, 11% of non-symptomatic individuals had a hard-to-treat bacteria that spreads easily; 25% of the bacteria tested had genes that allow them to spread their resistance.
"As graphic as it is, we have to show parents because teens are going online looking for challenges and recreating them," said education specialist Stephen Enriquez.
ALIS has previously been designated orphan drug status, breakthrough therapy status and a Qualified Infectious Disease Product.
A total of 113,650 deaths or a rate of 34.10 per 100,000 persons were due to infectious diseases in the United States in 2014, compared with 72,220 deaths or a rate of 41.95 deaths per 100,000 persons in 1980.
For the 327 patients who underwent histologic analysis, improvement in the atrophy grade at the gastric corpus lesser curvature from baseline was observed in 48.4% of the patients in the treatment group and in 15% of those in the placebo group.
Treatment of cryptococcal meningitis with two weeks of flucytosine and fluconazole was noninferior to two weeks of amphotericin B.
However, significantly fewer total antibiotics (relative risk [RR], 0.78) and antibiotics for respiratory tract infection (RR, 0.74) were prescribed for integrative medicine GP surgeries versus conventional GP surgeries.
The researchers found that during the 3-year study period, about 98 million outpatient antibiotic prescriptions were filled by 39 million insurance beneficiaries. Azithromycin, amoxicillin, amoxicillin/clavulanate, ciprofloxacin, and cephalexin were the most commonly prescribed antibiotics.
Among humans who died of sepsis, bacterial taxa detected in their brains were distinct from those who died of noninfectious causes and were correlated with S100A8/A9 expression.
The researchers included sex, age, duration of pain, guarding, pain migration, maximal tenderness in the right-lower quadrant, and absolute neutrophil count in the final pARC model. The pARC showed near perfect calibration in the validation sample as well as a high degree of discrimination (area under the curve, 0.85).