Bacterial Infections

Xerava Now Available for Treating Complicated Intra-Abdominal Infections

By October 12, 2018

As Xerava is a fully-synthetic fluorocycline antibacterial that is structurally similar to tetracyclines, treatment is contraindicated in patients with known hypersensitivity to tetracycline-class antibacterial drugs.

Nine Cases of Polio-Like Illness Suspected in Children in Illinois

October 12, 2018

Since 2015, Illinois has had 4 confirmed cases of acute flaccid myelitis. Symptoms include sudden limb weakness, loss of muscle tone and reflexes, facial and eyelid drooping, facial weakness, difficulty moving the eyes, swallowing difficulty, or slurred speech, according to the CDC.

Amikacin Liposome Inhalation Plus Antibiotics Effective in MAC Lung Disease

October 12, 2018

Within 6 months, 23% of patients with Mycobacterium avium complex lung disease who had received add-on amikacin liposome inhalation suspension had a culture conversion.

Patient Develops Glandular Tularemia After Taking Care of Sick Cat

By October 11, 2018

The 68-year-old patient reported having a fever for 1 week followed by progressive, painful swelling on the right side of his neck for 2 months.

Low Recurrence With Shortened IV Abx Course in GBS Bacteremia

October 11, 2018

The researchers found that 79 and 21% of the 775 infants who were diagnosed with uncomplicated, late-onset GBS bacteremia received a prolonged IV course and a shortened course, respectively.

Vitamin C Treatment May Be Beneficial for Sepsis but Duration, Dose Unclear

October 11, 2018

Vitamin C was associated with lower mortality rates, shorter lengths of ICU stay, and shorter durations of vasopressor use in patients with sepsis.

Flea-Borne Typhus Outbreak in Los Angeles County

October 10, 2018

"Since the disease is spread by fleas, it is possible that endemic typhus could be transmitted year-round. Right now, it's hard to speculate on why we are seeing more cases," said Anne Rimoin, PhD, an associate professor of epidemiology at the University of California School of Public Health.

Polio-Like Condition in Children on Rise Again in the United States

October 10, 2018

After the 120 cases in 2014, there were 22 in 2015, 149 in 2016, and 33 last year, according to the agency.

Vitamin D Deficiency Associated With Sepsis Mortality

October 09, 2018

Vitamin D deficiency is associated with increased risk for sepsis mortality in postmenopausal women, which was seen in all ages.

Cure Rate of Intra-Abdominal Infection With Short vs. Prolonged Therapy

October 09, 2018

No significant differences in clinical cure rates were observed between short-course and prolonged-course antimicrobial therapy in patients with intraabdominal infections.

Delafloxacin Equally Effective as Vancomycin/Aztreonam for ABSSSI

October 08, 2018

Treatment with intravenous and oral delafloxacin, a fluoroquinolone antibiotic with gram-negative and gram-positive activity, was comparable to vancomycin/aztreonam in improving clinical signs and symptoms in acute bacterial and skin structure infections.

Daptomycin + Fosfomycin Compared to Daptomycin Monotherapy in MRSA Bacteremia

October 05, 2018

The combination of daptomycin with fosfomycin demonstrates increased efficacy in treating methicillin-resistant Staphylococcus aureus bacteremia compared with daptomycin alone.

Oral Ciprofloxacin Effective in Treatment of Bacteremia

October 04, 2018

Oral ciprofloxacin has been found to be an effective option for gram-negative bacteremia treatment.

Nuzyra Approved for CABP, Acute Skin/Skin Structure Infections

By October 03, 2018

The approval was based on Phase 3 data from 2 studies in ABSSSI, where treatment with Nuzyra was compared with linezolid, and 1 study in CABP comparing Nuzyra with moxifloxacin. Across all 3 trials, Nuzyra was found to be effective and generally safe and well-tolerated.

First Human Case of Rat Strain of Hepatitis E Seen in Hong Kong

October 02, 2018

The case is "a wake-up call," according to Yuen Kwok-yung, MD, chairman of the infectious diseases section of the microbiology department at the university.

Arikayce Approved to Treat <i>Mycobacterium Avium</i> Complex Lung Disease

By October 01, 2018

Arikayce is intended for oral inhalation use and is administered via the Lamira Nebulizer System only.

CDC: Congenital Syphilis More Than Doubled Since 2013

September 28, 2018

Congenital syphilis up from 362 cases in 2013 to 918 in 2017, with 46.17 percent increase since 2016

Antibiotic Tx Appears to Be a Reasonable Option for Uncomplicated Acute Appendicitis

By September 26, 2018

The study included 530 patients, aged 18 to 60 years, with computed tomography-confirmed uncomplicated acute appendicitis.

Critics Demand Stop to 'Guinea Pig' Sepsis Clinical Trial

September 26, 2018

The Clovers trial seeks to determine which 1 of 2 therapeutic options - limiting fluids and starting vasopressors, or adding intravenous fluids and holding off on drug therapy - works best to curb sepsis.

Contezolid Gets QIDP, Fast Track Status for Acute Bacterial Skin/Skin Structure Infections

By September 21, 2018

The structure of contezolid was designed to potentially reduce the risk of hematological toxicity associated with this class of antibiotics.

Multidrug-Resistant <i>Campylobacter</i> Outbreak Linked to Pet Store Puppies

By September 20, 2018

Of the 149 puppies investigated, 142 (95%) received ≥1 courses of antibiotics, raising concern that antibiotic use may have led to development of resistance.

Multivalent Pneumococcal Conjugate Vaccine Gets Breakthrough Tx Designation

By September 20, 2018

The Breakthrough designation follows an FDA examination of results from a Phase 2 randomized, double-blind trial which evaluated the safety and immunogenicity of the treatment in adults aged 60 to 64 years.

Final CDC Update on <i>Salmonella</i> Linked to Backyard Poultry

September 17, 2018

People who became ill said they got live chicks and ducklings from relatives and from businesses such as feed supply stores, websites, and hatcheries, the CDC said.

Piperacillin-tazobactam likely less effective than meropenem for gram-negative bacteremia

September 14, 2018

In this randomized controlled trial, piperacillin-tazobactam was not found to be non-inferior to meropenum for all-cause mortality at 30 days among patients with gram-negative bacteremia.

Positive Results for Zerbaxa in Phase 3 Study of Ventilated HABP, VABP Patients

By September 11, 2018

The full findings from the study will be presented at a future scientific conference; Merck plans to include the data in a supplemental New Drug Application for Zerbaxa which will be submitted to the Food and Drug Administration.

Patient's Black Hairy Tongue Linked to Antibiotic Therapy

By September 10, 2018

The case involved a 55-year-old female patient who had been admitted to the hospital after suffering injuries from a car accident.

NICU Antibiotic Use Rates Declined From 2013 to 2016

September 10, 2018

There was no correlation between the 2016 AUR and either proven infection or necrotizing enterocolitis. However, there was an association between the 2016 regional NICU AUR and surgical volume, mortality rate, and average length of stay

Gaps in Prevention, Management of Tickborne Diseases Identified

September 06, 2018

Diagnostic and surveillance limitations and lack of treatment options, vaccines hamper efforts

130 Now Sickened by <i>Salmonella</i>-Tainted Honey Smacks Cereal

September 06, 2018

The cereal under recall includes Honey Smacks 15.3 oz. size with the UPC code of 3800039103 and a Best if Used by Date of JUN 14, 2018, through JUN 14, 2019.

CDC: Increase in Rate of STDs for Fourth Consecutive Year in US

September 05, 2018

Nearly 2.3 million total cases of chlamydia, gonorrhea, syphilis diagnosed in the United States in 2017