Bacterial Infections

Unique Presentation of SJS in a Female Patient Treated With TMP-SMX

By January 17, 2019

The patient, who presented to the clinical office complaining of dysuria, was diagnosed with a urinary tract infection and was prescribed TMP-SMX.

FDA Fast-Tracks Novel Oral Antibiotic for <i>C. difficile</i> Infection

By January 16, 2019

The investigational drug is currently in Phase 1 development, with completion expected in the second quarter of 2019.

FDA: Food Inspections to Resume Despite Ongoing Funding Lapse

By January 16, 2019

The news comes after FDA Commissioner Scott Gottlieb, MD announced last week a plan to recall some furloughed workers to conduct inspections.

How the Government Shutdown Affects FDA Activities

By January 11, 2019

The consequence of the shutdown means the budget appropriated by Congress for the Agency is on hold, resulting in ~7000 of it's 17,000 employees being furloughed.

CDC: <i>E. Coli</i> Outbreak Linked to Romaine Lettuce Is Over

January 11, 2019

25 people were hospitalized, including two who developed kidney failure; no deaths reported

Nine Cases of Wound Botulism ID'd in Injection Drug Users

January 09, 2019

Among persons who inject drugs, 9 cases of wound botulism were identified in Southern California from September 2017 to April 2018, according to research published in the January 4 issue of the US Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

USPSTF Affirms Guidance for Hep B Screening at First Prenatal Visit

January 09, 2019

The US Preventive Services Task Force (USPSTF) recommends hepatitis B virus (HBV) infection screening in pregnant women at their first prenatal visit.

Antibiotics Prescribed for Children More Often at Nonpediatric EDs

January 08, 2019

Compared with pediatric emergency departments, antibiotics were prescribed more frequently in nonpediatric emergency departments (24 vs 20%).

Antibiotic Recalled After Rubber Flecks Found in Reconstituted Vials

By January 07, 2019

The issue was identified upon standard visual inspection before administration to the patient and was not observed prior to reconstitution.

College Students at Increased Risk for Serogroup B Meningococcal Disease

January 02, 2019

Students, parents, health care providers should be aware of the availability of MenB vaccines

NDAs Submitted for Oral, IV Formulations of Lefamulin for CABP

By December 26, 2018

The NDA submissions included data from two Phase 3 trials (LEAP 1 and LEAP 2) which evaluated the safety and efficacy of IV and oral lefamulin vs moxifloxacin in the treatment of adults with CABP, including the option to switch from IV to oral administration and a short course oral treatment with lefamulin.

Trial Evaluating <i>Staphylococcus aureus</i> Vaccine Halted

By December 26, 2018

The aim of the STRIVE study was to investigate whether a single vaccination given 10-60 days before spinal surgery could prevent S. aureus infection in adults undergoing elective spinal fusion surgery.

FDA: Fluoroquinolones Linked to Increased Risk of Aortic Aneurysm or Dissection

By December 21, 2018

A review of cases reported to the FDA Adverse Event Reporting System (FAERS) and 4 observational studies (between 2015 and 2018) showed an increased risk of aortic aneurysm or dissection associated with fluoroquinolone use.

Infection Control Compliance Not Tied to Knowledge

December 21, 2018

Home health care workers' beliefs about infection prevention seem to have a greater influence on prevention protocol compliance than their absolute knowledge of infection control practices, according to a study published in the November issue of the American Journal of Infection Control.

Stethoscopes in ICU Show High Levels of Bacterial Contamination

December 17, 2018

The researchers found that the highest levels of bacterial contamination were on practitioner stethoscopes, followed by patient-room stethoscopes.

SGLT2 Inhibitors and Urinary Tract Infections: What's the Link?

By December 17, 2018

For this study, the authors identified randomized controlled trials (RCTs) that compared SGLT2 inhibitors with placebo, no treatment, or another antidiabetic agent and reported on UTI outcome.

CDC: More Cases in <i>Salmonella</i> Outbreak Linked to Recalled Beef

December 14, 2018

The number of illnesses in a Salmonella outbreak linked to beef products from Arizona-based JBS Tolleson Inc. now stands at 333 in 28 states, according to the CDC.

Infections Linked to Increased Later Risk for Mental Disorders

December 06, 2018

Subsequent risk increased with infections requiring hospitalization, treatment with anti-infective agents

Novel <i>H. pylori</i> Eradication Therapy Effective in Phase 3 Trial

By December 04, 2018

The ERADICATE Hp2 trial enrolled 455 dyspepsia patients at 55 sites across the US and randomized them to receive 4 capsules, 3 times daily, of either Talicia or the active comparator (amoxicillin 250mg and omeprazole 10mg), for a period of 14 days.

Safe to Eat Romaine Lettuce Again, but Check Where Grown

November 28, 2018

Starting as early as this week, romaine lettuce sold in stores will carry labels listing the region where the produce was grown along with its harvest date, the FDA said.

Early Antibiotic Use May Be Tied to Higher Childhood Body Weight

November 27, 2018

The researchers identified 362,550 eligible children (52% boys, 27% African-American, 18% Hispanic), of whom 58% received at least 1 antibiotic prescription at <24 months of age.

Probiotics Show No Benefits for Pediatric Acute Gastroenteritis

November 26, 2018

No benefits seen with Lactobacillus rhamnosus GG or L. rhamnosus R0011 and L. helveticus R0052

Another <i>E. coli</i> Outbreak Linked to Romaine Lettuce

November 21, 2018

So far, 32 people across 11 states have become sick with E. coli after eating romaine lettuce

FDA Approves New Treatment for Travelers' Diarrhea

By November 19, 2018

Aemcolo is a broad spectrum, semi-synthetic, orally-administered, minimally-absorbed antibiotic designed to allow for delayed release to the colon.

Climate Change Expected to Lead to Rise in Lyme Disease

November 19, 2018

Results indicate an inverted U-shaped relationship, consistent with patterns of tick survival and host-seeking behavior.

CDC: Record Number of Tickborne Disease Cases in US Last Year

November 15, 2018

There were 36,000 cases of Lyme disease in 2016, NBC News reported. Other tickborne disease cases in 2017 included: ehrlichiosis (7718), Rocky Mountain spotted fever (6248), babesiosis (2368), tularemia (239), and Powassan virus (33), according to the CDC.

New Antibiotic Shows Promise as Potential Treatment for Uncomplicated Gonorrhea

By November 09, 2018

Unlike other antibiotics used to treat gonorrhea, zoliflodacin, a spiropyrimidinetrione antimicrobial agent, works by inhibiting DNA biosynthesis by arresting the cleaved covalent gyrase complex, thereby impeding bacterial growth.

Progress Toward Goals in Global Health Is Slowing

November 09, 2018

The researchers found there have been global successes in mortality, such as the large decline for under-5s, but other mortality patterns show cause for concern.

Possible <i>Salmonella</i> Prompts Duncan Hines Cake Mix Recall

November 08, 2018

US health officials are investigating a Salmonella outbreak in which 5 people have become ill. Some said they ate a cake mix before becoming ill, and some may have eaten raw batter.

Hypoglycemia Following Antifungal Tx in Patient With Type 1 Diabetes

By November 07, 2018

"This is the first report of decreased insulin requirements in a patient with T1DM correlating with micafungin administration," noted the authors.