Jenny Ko, PharmD

All articles by Jenny Ko, PharmD

Diclofenac Sodium 1% Gel Minimizes Drug-Drug Interaction-Related Adverse Events

Minimal systemic distribution of topical diclofenac sodium gel resulted in a lower incidence of major or moderate drug-drug interactions associated with oral diclofenac and reduced the risk of drug interaction-related adverse events. Study results were reported by Matthew Wieman, MD, from Endo Pharmaceuticals, John H. Peniston, DO, from Novartis Consumer Health, and colleagues at the American Pain Society’s 31st Annual Scientific Meeting.

Vitamin D Deficiency Associated With Increased Osteoarthritis Symptoms and Reduced Pain Threshold

Study investigators presented data from the UPLOAD (Understanding Pain & Limitations in OsteoArthritic Disease) study at the American Pain Society’s 31st Annual Scientific Meeting demonstrating that hydroxyvitamin D levels <25ng/mL were associated with an increase in osteoarthritis (OA) symptoms and a decreased threshold for pressure pain.

OROS Hydromorphone ER: No Sustained Efficacy for Osteoarthritis Pain vs. Placebo

A randomized, placebo-controlled, double-blind study evaluating OROS hydromorphone ER for reducing moderate-to-severe osteoarthritis (OA) pain showed that though the treatment is effective in treating chronic OA, it failed to demonstrate sustained efficacy vs. placebo + rescue medication, “perhaps due to higher use of rescue medication in the latter group,” investigators concluded during a presentation at the American Pain Society’s 31st Annual Scientific Meeting.

Single-Tablet Ibuprofen-Famotidine Reduces NSAID-Associated Upper GI Ulcers

A single-tablet combination of ibuprofen 800mg and famotidine 26.6mg (HZT-501) administered three times daily was found to reduce nonsteroidal antiinflammatory drug (NSAID)-associated upper gastrointestinal (GI) ulcers in patients overall, as well as in each subset for those taking NSAIDs for osteoarthritis, rheumatoid arthritis, and chronic pain, a study presented during the 2012 American Academy of Pain Medicine Annual Meeting has found.