Revaccination of children with live-attenuated influenza vaccine (LAIV) over 2 consecutive seasons did not reduce vaccine efficacy, and was similar to, or higher than, efficacy of a single LAIV administration in the second season.
The investigational Intradermal (ID) Quadrivalent Inactivated Influenza Vaccine (IIV4-ID) tested in a Phase 3 clinical trial during the 2012-13 influenza season produced antibody responses to B strains that were superior to a licensed split-virion trivalent influenza vaccine (IIV3-ID) containing the alternate strain, and noninferior for the A and matched B strains.
The QUAD regimen—daclatasvir and asunaprevir plus peginterferon alfa-2a and ribavirin (DCV+ASV+pegIFN/RBV)—demonstrated high sustained virologic response rates of 93% at post-treatment Week 12 (SVR12) in genotype 1 (GT 1) and 100% in genotype 4 (GT 4) patients with hepatitis C virus who were prior null or partial responders to pegIFN/RBV.
Compared with cefazolin, perioperative monotherapy with vancomycin or clindamycin in pediatric spine fusion cases resulted in a 251.5% increase in rate of surgical site infections (SSIs).
Treatment with rilpivirine/emtricitabine/tenofovir DF (RPV/FTC/TDF) was noninferior to efavirenz (EFV/FTC/TDF) in treatment-naïve patients with HIV at Week 48.
No difference in clinical outcomes was found between subjects with HIV randomly assigned to a non-nucleoside reverse-transcriptase inhibitor (NNRTI) versus ritonavir-boosted protease inhibitor (PI/r)-based initial antiretroviral therapy (ART).
S-649266, a novel catechol-substituted siderophore cephalosporin for injection, showed potent in vitro activity against a broad spectrum of Gram-negative bacteria.
Mupirocin decreased the risk of Staphylococcus aureus infection among both dialysis and adult ICU patients in a meta-analysis of 37 studies.
