Debra Hughes, MS

Despite initial recognition of opioid-induced androgen deficiency (OPIAD) as a possible consequence of opioid use more than four decades ago, few studies have systematically investigated hormonal changes induced by long-term opioid administration.

The investigators found switching data for 12 studies in rheumatic diseases.

Several recent studies have shown that a delay in diagnosis of PsA leads to a worse outcome.

Treatment with single tablet sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) for 12 weeks “is a highly effective salvage therapy” for patients who did not previously achieve sustained virologic response (SVR) following treatment with non-NS5A inhibitor-containing direct-acting antivirals (DAAs), results from the POLARIS-4 study presented at The Liver Meeting® 2016 have shown.

A fixed-dose combination of pangenotypic direct-acting antivirals was “highly effective” in treatment-naïve patients with hepatitis C virus (HCV) genotypes (GT) 1, 2, and 3

No clinically significant changes in heart rate or cardiac adverse events were observed in patients with hepatitis C virus (HCV) infection on beta blockers receiving sofosbuvir (SOF)-based regimens, results of a study presented at The Liver Meeting® have found.

The all-oral, ribavirin-free glecaprevir/pibrentasvir regimen achieved high SVR12 rates in non-cirrhotic patients with hepatitis C virus (HCV) genotype (GT) 4, 5, and 6 infection, the phase 3 ENDURANCE-4 study concluded at The Liver Meeting® 2016.

No resistance to tenofovir alafenamide (TAF) was detected through week 48 in adults with chronic hepatitis B virus (HBV), regardless of whether they were treatment-naïve or -experienced, results of two phase 3 studies presented at The Liver Meeting® 2016 have shown.

Use of telbivudine and tenofovir in middle-to-late pregnancy was equally effective in reducing mother-to-infant chronic hepatitis B virus (HBV) infection vertical transmission, a real world study in China reported at The Liver Meeting® 2016

In patients with early RA, conventional synthetic DMARDs are recommended as first-line therapy