Concomitant Use of Lithium and Antipsychotics May Be Neurotoxic
Concomitant use of lithium and antipsychotics, particularly haloperidol, may be associated with neurotoxicity in some patients.
All articles by Contributing Writer
COPD Exacerbation Frequency and Treatment Strategy Differs by GOLD Stage
Patients with COPD who have the most severe airflow obstructions according to the GOLD strategy document had more exacerbations than those with less severe obstructions, and were more likely to be treated with both systemic corticosteroids and antibiotics.
Obesity Does Not Increase ICU Mortality Rate in Acute Respiratory Failure
Researchers examined whether obesity is a factor in the mortality of patients with acute respiratory failure that requires intubation.
PONENTE Trial May Provide Guidance for OCS Tapering in Asthma
Benralizumab has been found to be associated with a reduction in oral corticosteroid (OCS) use while maintaining asthma control for patients with OCS-dependent severe asthma.
Aclidinium Delays COPD Event Onset, Does Not Increase MACE Risk
Individuals with moderate to very severe COPD and cardiovascular risk factors did not have an increased risk for all-cause mortality or major adverse cardiovascular event occurrence with the use of aclidinium.
Factors Affecting Lung Function Improvement With Omalizumab
Researchers compared lung function improvements within the combination subgroups of high/low eosinophil levels and high/low FEV1 reversibility in patients with moderate to severe asthma treated with omalizumab vs patients who took placebo.
Pulmonary Vasodilators Reduce Mortality in Pediatric Pulmonary Hypertension
Investigators assessed the efficacy and safety of pulmonary vasodilators to treat pediatric pulmonary arterial hypertension.
Mepolizumab and High-Baseline EDN Linked to Lower Asthma Exacerbation Rates
Investigators sought to determine a link between baseline blood eosinophil counts and certain biomarkers and observed that mepolizumab-treated individuals with elevated baseline levels of eosinophil-derived neurotoxin experienced the greatest reduction in exacerbation rates.
Switching and Combining Biologics for the Treatment of Severe Asthma
The study was designed to examine the prescribing patterns at a large academic teaching center to identify patients who have taken more than one biologic asthma medication, either sequentially or simultaneously, and to analyze the outcomes.
Moderate to Acute Asthma Benefits From Maintenance and Reliever Therapy
Investigators examined the effectiveness of low-dose beclomethasone/formoterol maintenance and reliever therapy vs beclomethasone/formoterol plus salbutamol to lower the exacerbation rate in patients with moderate to acute asthma.
