The Hailie sensor attaches to the asthma or chronic obstructive pulmonary disease (COPD) inhaler to monitor and help patient adherence.
Study authors performed a post hoc pooled analysis of data from 10 trials to assess the safety and efficacy of umeclidinium/vilanterol in elderly symptomatic patients with COPD.
The researchers identified 3 asthma-related intubations (2 in the inhaled-glucocorticoid group, 1 in the combination therapy group) and 2 asthma-related deaths (both in the combination-therapy group) in 4 patients among the 36,010 patients in the intention-to-treat study.
Greater risks were seen following a severe exacerbation (incidence rate ratios, 2.58 and 1.97 for myocardial infarction and ischemic stroke, respectivley) than after a moderate exacerbation (incidence rate ratios, 1.58 and 1.45, respectively).
There was a correlation for non-rhinovirus pathogens with increased absolute risk of treatment failure by 13.1%; specifically, by 8.8, 24.9, and 34.1% for respiratory syncytial virus, influenza, and parainfluenza, respectively.
Identified viral pathogens were not associated with asthma exacerbation severity, but were linked to increased treatment failure. Evidence Rating Level: 2 (Good).
"Distinct immune-response clusters during infant RSV infection and their association with risk of recurrent wheeze provide insights into the risk factors for and mechanisms of asthma development," the authors write.
Cyclosiloxanes, parabens, and the fragrance marker diethyl phthalate (DEP) were found at the highest levels, with DEP found most frequently.
"These two trials show persuasively that treatment with budesonide-formoterol on an as-needed basis prevented the most serious outcomes of poorly controlled asthma," writes the author of an accompanying editorial.
Asthma medications, antibiotics, attention-deficit/hyperactivity disorder (ADHD) medications, topical agents, and antihistamines were the most commonly used medication classes in 2011 to 2014.
The researchers observed a decrease in asthma mortality among more deprived groups at younger ages. Five- to 44-year-olds in the most deprived quintile had 19% lower mortality than those in the least deprived quintile (IRR, 0.81).
The clinic claims its unapproved therapies can treat a number of serious diseases and conditions, including Parkinson's disease, amyotrophic lateral sclerosis (ALS), chronic obstructive pulmonary disease (COPD), heart disease, and pulmonary fibrosis.
The study authors examined data obtained from the 2007-2008 National Survey of Children's Health (NSCH) to determine the prevalence, risk factors, as well as the severity of asthma phenotypes.
The study aimed to determine the association between ICS therapy adherence and the occurrence of asthma exacerbations in patients with high blood eosinophil levels.
There was an increased incidence of asthma among birth home neighborhoods with low walkability (hazard ratio, 1.11). Low walkability in a given year of a child's life was associated with greater odds of ongoing asthma in the same year (odds ratio, 1.12).
The study authors reported, "The most commonly reported problems by youth were: (a) hard to remember when to take the asthma medication (54%) and (b) hard to use asthma medication at school (34%)."
Of the total 573 APFS dispensed, 1 malfunctioned and 1 was considered nonfunctional because it was not returned. The study authors also reported that patient-use error only led to 2 unsuccessful at-home administrations.
"To tailor asthma management conversations, clinicians should understand family-specific barriers and child-caregiver disagreements," the authors write.
The drug consists of fluticasone furoate, an inhaled corticosteroid (ICS), umeclidinium, a long-acting muscarinic antagonist, and vilanterol, a long-acting beta2-adrenergic agonist (LABA), delivered via an Ellipta dry powder inhaler.
Iatrogenic steroid-induced psychosis is a rare side effect of glucocorticoid therapy which is mostly seen in adults, although it has been reported in children and adolescents.
At the 12-week follow-up, the between-group difference for SGRQ favored the tai chi group (P<0.001). Similar results were seen for 6-minute walk distance, but there was no change in forced expiratory volume in one second.
The researchers found that the most effective case-finding tools were the peak flow meter alone, the peak flow meter plus WheezoMeter, and microspirometry alone.
Study authors concluded, "Combining tiotropium and olodaterol did not reduce exacerbation rate as much as expected compared with tiotropium alone."
The Smartinhaler sensor is a device installed onto a patient's inhaler to monitor and promote asthma and COPD medication adherence.