A report from the Department of Health and Human Services (HHS) found that 1 in 3 foster children sampled in 5 states received the drugs without treatment plans or follow-up.
The researchers found that 26.4% of adults met the definition of long-term use 1 year after the index prescription; they were prescribed a mean of 232.7 benzodiazepine days.
Results showed that discontinuation of any SNRI was associated with withdrawal symptoms, with the highest prevalence linked to venlafaxine and desvenlafaxine.
Discussions involving Internet challenges with children and adolescents should be as sensitive as those about sexuality and drug or alcohol use.
To update a previous review, researchers searched various databases from May 2012 to September 2017 to identify studies comparing the safety and efficacy of various PTSD interventions.
There was a significant correlation for anxiety levels with age, menopausal age, years since menopause, and depressive symptoms; multiple regression analysis predicted reduced BMD in the lumbar spine.
The researchers found that survivors of lymphoma and CLL contacted their general practitioner and medical specialist more often within the last year vs the control population.
Compared to placebo, selective serotonin reuptake inhibitors (SSRIs) were associated with a significantly higher risk of headache (risk ratio [RR] 1.06, 95% CI: 1.00 to 1.13; P =.045).
The researchers observed a positive correlation between clinically significant anxiety and future dementia in all studies. A meta-analysis was not conducted due to the heterogeneity between the studies.
The authors noted that treatment with SSRIs led to significantly greater improvement by the second week of treatment vs. SNRIs (P=0.0268); this benefit remained statistically significant through Week 12.
Data showed a significant effect on abstinence rates with the use of baclofen (odds ratio [OR] 2.67, 95% CI: 1.03, 6.93) but no other significant effects on treatment efficacy (heavy drinking days SMD -0.26, 95% CI: -0.68, 0.15) or mechanism of action (craving SMD: -0.13, 95% CI: -0.36, 0.09) were seen.
"Our results show that, at a population level, prescriptions of stimulants and antidepressant medications for children and adolescents do not appear to be prescribed at rates higher than the known rates for psychiatric conditions they are designed to treat," said the study's lead author, Dr. Ryan Sultan.
The 24-week assessment showed the largest difference between treatments. The WET group had significantly fewer dropouts than the CPT group (4 versus 25).
For this study, researchers from the University of Michigan College of Pharmacy investigated the available evidence for the use of pregabalin in benzodiazepine discontinuation.
After adjustment for potential confounders, exposed children had a 26% increased risk of ADHD compared with unexposed children.
Dose-dependent serious cardiac arrhythmias may be observed with higher dosages of ondansetron in those patients with certain pre-existing cardiac conditions.
Following completion of all treatments 12 (52%) of the 23 subjects who initially met PTSD Checklist-Military (PCL-M) for diagnosis no longer met the threshold criteria.
The researchers observed no correlation for panic disorder or GAD with maternal or neonatal complications of interest, in adjusted models.