Anesthetics

Drug Used for Reversal of Neuromuscular Block Recalled Due to Mislabeling

By July 02, 2018

Neostigmine Methylsulfate Injection, a cholinesterase inhibitor, is indicated to reverse the effects of non-depolarizing neuromuscular blockers after surgery.

AMA: Docs Declare Drug Shortages Public Health Emergency

June 26, 2018

The AMA will urge the Department of Health and Human Services and Department of Homeland Security to examine drug shortages as a national security initiative in response to hazards that pose a threat to the resilience of drug production.

Post-Op Pain Treatment Gets Breakthrough Therapy Designation

By June 25, 2018

The Company indicated that they will work towards an New Drug Application submission for the treatment in the second half of 2018.

Single-Use Lidocaine 1% Ampules Now Available

By June 19, 2018

The ampules are available immediately.

Children Can Drink Clear Fluids Until 1 Hour Before Anesthesia

June 15, 2018

Increased thirst and irritability are reported with prolonged fasting period, as well as detrimental physiological and metabolic effects. No increased risk of pulmonary aspiration was reported with a 1-hour clear fluid policy and studies demonstrated that the stomach was empty.

Dexmedetomidine Cuts γ-Aminobutyric Acid Receptor Function

June 13, 2018

The researchers found that dexmedetomidine reduced the etomidate-induced sustained increase in α5 γ-aminobutyric acid type A receptor cell-surface expression (etomidate: 146.4 ± 51.6%; etomidate + dexmedetomidine: 118.4 ± 39.1% of control).

Benefit of Liposomal Bupivacaine for Pain in TKA Questioned

June 04, 2018

The researchers found that liposomal bupivacaine was used in 21.2% of patients. Its use was not associated with a clinically meaningful reduction in inpatient opioid prescription, length of stay, or cost of hospitalization.

Atropine plus propofol similar to atropine plus atracurium and sufentanil for non-emergent intubation in neonates

May 03, 2018

In this randomized controlled trial, the frequency of prolonged desaturation during neonatal, nonemergent intubation was similar between atropine plus propofol compared to atropine plus atracurium and sufentanil.

Anesthesiologists Report Drug Shortages Impacting Patient Care

April 30, 2018

More than 95% of respondents reported that the shortages had an impact on patient care. Hydromorphone, fentanyl, morphine, bupivacaine, and epinephrine were the top drugs listed in short supply.

Multiple Anesthesia Exposures Affect Learning and Attention

April 26, 2018

The researchers found that those with multiple, but not single exposures, had an increased frequency of both learning disabilities and attention-deficit/hyperactivity disorder (hazard ratio for learning disabilities, 2.17) versus unexposed children.

Exparel Approved for Use as Interscalene Brachial Plexus Nerve Block

By April 09, 2018

Additionally, statistical significance vs placebo was also achieved in total postsurgical opioid consumption through 48 hours (P<0.0001); opioid-free subjects through 48 hours (P<0.01); and time to first opioid rescue through 48 hours (P<0.0001).

Clinical Effects of Ketamine &#43; Propofol Examined for Ped MRI Sedation

February 07, 2018

The researchers found that the ketamine-propofol group experienced significantly shorter recovery times; 38 versus 54 minutes; median difference, 14 minutes; P<0.001.

Is Complete Handover of Anesthesia Care Safe?

January 10, 2018

The primary outcome (composite of all-cause death, hospital readmission, or major postoperative complications within 30 postoperative days) occurred in 44 and 29% of the complete-handover and no-handover groups, respectively, in the unweighted sample.

Teva Relaunches Vecuronium Bromide for Injection

By August 02, 2017

Vecuronium Bromide for Injection, a non-depolarizing neuromuscular blocker, is indicated as an adjunct to general anesthesia.

LETS GEL KIT Available to Prevent Pain When Suturing

By July 18, 2017

The new Convenience Pack includes SuturaGel Methylcellulose Base, which is designed to reduce the amount of medication run-off from the treatment area.

Potential Microbial Growth Prompts Recall of Several Injectable Solutions

By June 16, 2017

The affected lots were distributed in the U.S, Dutch Antilles, Barbados, Canada, Philippines, Kuwait, and Singapore between January to June 2017.

Could Movies Act as an Alternative Anesthetic?

May 10, 2017

Videos promote relaxation and stillness without medication, researchers say

New Warning Added to General Anesthetics, Sedation Drugs

By April 27, 2017

For children aged <3 years, the FDA is advising to not delay or avoid surgeries or procedures when medically necessary.

Propofol Use Linked to Rare Case of Fatal Pancreatitis

April 26, 2017

57-year-old woman developed severe abdominal pain with nausea, vomiting after thyroidectomy

Intranasal Drug Delivery Increasingly Popular in the ER

April 24, 2017

Many benefits to nasal administration, including reduction in spread of infection

IV Placements Increases Jet Injection of Lidocaine

March 10, 2017

The researchers found that over seven months there was an increase in jet injection of lidocaine use with IV placement to 54%.

Review: Efficacy of Intranasal Drug Delivery in Emergency Settings

By March 07, 2017

In this study, researchers reviewed the evidence on the use of IN administration for several medications commonly used in the emergency department.

Post-Op Opioid-Sparing Effect of Ketamine Analyzed

By December 28, 2016

According to a meta-analysis published in Pediatric Drugs, ketamine was not associated with a postoperative opioid-sparing effect.

FDA: New Warning for Anesthetic/Sedative Use in Children, Pregnant Women

December 14, 2016

Since 1999, the FDA has been evaluating the potential adverse effects of general anesthetics and sedatives on children's brain development.

Local vs. General Anesthetic in TAVR

November 21, 2016

For patients undergoing transcatheter aortic valve replacement (TAVR), local anesthetic (LA) is as safe as general anesthetic (GA), with shorter procedure time and number of days in the hospital, according to a study published in The American Journal of Cardiology.

New Virtual Reality Tool Shows Clinicians How to Administer Exparel in TKA

By November 11, 2016

Exparel, an amide local anesthetic, is FDA approved for single-dose infiltration into the surgical site to produce postsurgical analgesia.

Grades, IQ Assessed of Children Who Received Anesthesia as Infants

November 08, 2016

Children exposed to surgical anesthesia before the age of 4 may have slightly lower school grades and IQ scores in their late teen years, according to a study published online in JAMA Pediatrics.

Hospira Recalls Fentanyl Citrate Inj Due to Defective Vials

By November 07, 2016

Hospira announced a voluntary recall of 3 lots of Fentanyl Citrate Injection 50mcg/mL due to confirmed ampules with broken tips.

Combining Procedures Could Help Limit Anesthesia Exposure in Children

October 26, 2016

Few pediatric patients having a dental procedure combined with another surgical procedure require unplanned admission for perioperative concerns.

Reducing Pre-Op Stress in Kids: iPad vs. Midazolam

By August 30, 2016

Electronic tablets such as iPads demonstrated similar efficacy as a sedative commonly administered to children before general anesthesia, a new study has found.