Peanut allergy effectively treated with oral immunotherapy

November 23, 2018

A new orally available immunotherapy consisting of peanut protein, AR101, may provide a clinically useful method for treating patients with peanut allergy

Prevalence of Food Allergy 7.6% in US Children

November 19, 2018

Of the food-allergic children, 42.3 and 39.9% reported 1 or more severe FA and multiple FAs, respectively. Nineteen and 42.0% reported 1 or more FA-related emergency department visits in the previous year and 1 or more lifetime emergency department visits, respectively.

AR101 May Protect Against Accidental Peanut Exposure

By November 18, 2018

More than 67% of patients who received AR101 were able to ingest a dose of 600 mg or more of peanut protein at the exit food challenge, without dose-limiting symptoms

Olopatadine/Mometasone Nasal Spray Effective for Perennial Allergic Rhinitis

November 18, 2018

GSP301 treatment was associated with a significant improvement in reflective and instantaneous Total Nasal Symptom Scores compared with placebo.

Increased Medication Burden for Patients With Both Asthma and Allergies

November 18, 2018

Patients with both asthma and allergies had a significant increase in the number of prescriptions dispensed for controller medications.

Eosinophilic Esophagitis Symptoms Reduced With Anti-Interleukin 13 Antibody

November 18, 2018

Significantly greater reductions in the mean esophageal eosinophil counts occurred in patients who received the humanized anti-interleukin 13 antibody, RPC4046.

GSP301 Nasal Spray Improves QoL in Seasonal Allergic Rhinitis

November 18, 2018

Patients who received a fixed-dose combination nasal spray showed significantly improved Physician-assessed Nasal Symptom Scores compared with those who received placebo.

Does Cetirizine Provide More Benefits Than Diphenhydramine for Acute Urticaria?

November 16, 2018

The change from baseline in 2-hour pruritus score was shown to be statistically noninferior from IV cetirizine to IV diphenhydramine, in favor of IV cetirizine.

Oralair Approved for Younger Patients With Grass Pollen Allergy

By November 14, 2018

Oralair is indicated as immunotherapy for the treatment of grass pollen-induced allergic rhinitis with or without conjunctivitis confirmed by positive skin test or in vitro testing for pollen specific IgE antibodies for any of the 5 grass species contained in this product.

Pharmacist-led educational intervention decreases inappropriate medications for older adults

November 13, 2018

Inappropriate prescribing of medications such as benzodiazepines, antihistamines, and anti-inflammatory drugs for older adults can lead to adverse events and hospitalization. Targeted educational efforts to deprescribe these medications have found to be successful.

FDA: Lifted Label Defect May Delay Emergency Treatment With EpiPen

By November 05, 2018

To ensure that the auto-injector can be easily removed from the carrier tube, healthcare providers should inspect the product prior to dispensing.

Avocado Implicated in Several Food Protein-Induced Enterocolitis Syndrome Cases

By October 29, 2018

FPIES is a gastrointestinal food-associated hypersensitivity that often affects infants and toddlers and is marked by vomiting, diarrhea, fatigue, and pallor.

BLA for Novel Peanut Allergy Treatment Submitted to FDA

By October 22, 2018

Viaskin Peanut, an epicutaneous immunotherapy (EPIT), delivers small amounts of peanut protein through a wearable patch to induce desensitization.

Dupilumab Studies Show Benefit in Chronic Rhinosinusitis With Nasal Polyps

By October 16, 2018

In both studies, at 24 weeks, patients treated with dupilumab plus corticosteroid nasal spray experienced a 51% and 57% improvement in nasal congestion/obstruction severity vs 15% and 19% improvement with nasal spray alone.

Omalizumab Improves Lung Function in Persistent Allergic Asthma

October 12, 2018

Patients with moderate to severe persistent allergic asthma who were treated with omalizumab experienced greater improvements in lung function after 16 weeks compared with those treated with placebo.

Xolair Prefilled Syringe Formulation Gets FDA Approval

By October 01, 2018

The PFS formulation eliminates the need to reconstitute the solution before administration.

High-Risk Anticholinergics Prescribed to Six Percent of Elderly

September 25, 2018

The researchers found that a high-risk anticholinergic prescription was listed for 6.2% of visits of older adults between 2006 and 2015, representative of 14.6 million total visits nationally.

Addition of High-Dose Guaifenesin Benefits Patient With Chronic Respiratory Conditions

By September 13, 2018

According to the report, the patient complained of a non-productive cough, accumulation of mucus, and post-nasal drip and requested a thorough assessment of her medical conditions.

Asthma Medicine Recalled Due to Tablet Mix-Up That May Pose Safety Risk

By August 31, 2018

The risk of a mixing-up the treatments is especially high for pregnant women, says the Food and Drug Administration (FDA), as losartan is indicated to treat high blood pressure and could harm or kill a fetus.

An Allergy to Red Meat May Be Tied to Heart Disease

August 31, 2018

The researchers found that 26% of patients had antibodies to α-Gal, indicating sensitivity to red meat. The sensitized patients had significantly higher levels of arterial plaque (30% higher) vs non-sensitized patients.

Many ED Visits for Antibiotic Adverse Drug Events in Children

August 31, 2018

Based on 6542 surveillance cases, the researchers estimated that 69,464 emergency department visits were made annually for antibiotic ADEs among children aged 19 years or younger from 2011 to 2015.

Manufacturers Issue Statements Regarding Epinephrine Auto-Injector Supply

By August 15, 2018

In May, the Food and Drug Administration posted a drug shortage alert, adding Mylan's EpiPen (epinephrine injection) to the drug shortage list.

Xolair Designated Breakthrough Therapy for Food Allergies

By August 13, 2018

The FDA designation was supported by data from 7 studies evaluating the safety and efficacy of Xolair against various food allergens (eg, peanut, milk, egg, others).

Child-Targeted Gluten-Free Products No Healthier

July 23, 2018

Compared with child-targeted products without a GF claim, child-targeted GF products had lower levels of sodium, total fat, and saturated fat, and also had less protein, and a higher percentage of calories from sugar.

FDA Announces New Drug Shortages Task Force

By July 12, 2018

Gottlieb said "The charge to this new task force is to look for holistic solutions to addressing the underlying causes for these [drug] shortages."

Aspirin Desensitization May Improve Alcohol-Induced Symptoms in AERD Patients

By July 11, 2018

In addition to respiratory sensitivity to aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), patients with AERD oftentimes experience an additional allergic reaction when drinking alcohol.

Tick-Caused Meat Allergy on the Rise in the United States

July 09, 2018

Hives, skin rash, stomach problems, headaches, and trouble breathing are among the symptoms of the meat allergy. There is no treatment or cure.

Penicillin Allergy Linked to MRSA, <i>C. Difficile</i> Risk

June 29, 2018

Also among patients with penicillin allergy, the adjusted incidence rate ratios for antibiotic use were 4.15, 3.89, and 2.1 for macrolides, clindamycin, and fluoroquinolones, respectively. Increased use of β-lactam alternative antibiotics accounted for 55 and 35% of the increased risk of MRSA and C. difficile, respectively.

Most Adults Don't Use Their Epinephrine Auto-Injectors During Reactions

By June 21, 2018

Most adults (52%) reported that an EAI was not used during their most severe reaction, even though it would have been beneficial, 45% said they didn't have it with them at the time.

Pediatric Chronic Rhinosinusitis: Treatment Options to Consider

By June 20, 2018

Because determining an appropriate treatment plan for a patient depends on the subtype of the disease, it is imperative for providers to know and understand the underlying mechanisms of CRS as well as the components included in a medical evaluation of a patient.