Allergic Disorders

Limited Doses of FDA-Approved EpiPen Generic Now Available

By November 28, 2018

The generic version of the EpiPen Jr (epinephrine injection, USP) 0.15mg as well as additional supply of the generic version of the EpiPen Auto-Injector 0.3mg will be made available in 2019.

Peanut allergy effectively treated with oral immunotherapy

November 23, 2018

A new orally available immunotherapy consisting of peanut protein, AR101, may provide a clinically useful method for treating patients with peanut allergy

Prevalence of Food Allergy 7.6% in US Children

November 19, 2018

Of the food-allergic children, 42.3 and 39.9% reported 1 or more severe FA and multiple FAs, respectively. Nineteen and 42.0% reported 1 or more FA-related emergency department visits in the previous year and 1 or more lifetime emergency department visits, respectively.

AR101 May Protect Against Accidental Peanut Exposure

By November 18, 2018

More than 67% of patients who received AR101 were able to ingest a dose of 600 mg or more of peanut protein at the exit food challenge, without dose-limiting symptoms

Increased Medication Burden for Patients With Both Asthma and Allergies

November 18, 2018

Patients with both asthma and allergies had a significant increase in the number of prescriptions dispensed for controller medications.

Olopatadine/Mometasone Nasal Spray Effective for Perennial Allergic Rhinitis

November 18, 2018

GSP301 treatment was associated with a significant improvement in reflective and instantaneous Total Nasal Symptom Scores compared with placebo.

Eosinophilic Esophagitis Symptoms Reduced With Anti-Interleukin 13 Antibody

November 18, 2018

Significantly greater reductions in the mean esophageal eosinophil counts occurred in patients who received the humanized anti-interleukin 13 antibody, RPC4046.

GSP301 Nasal Spray Improves QoL in Seasonal Allergic Rhinitis

November 18, 2018

Patients who received a fixed-dose combination nasal spray showed significantly improved Physician-assessed Nasal Symptom Scores compared with those who received placebo.

Does Cetirizine Provide More Benefits Than Diphenhydramine for Acute Urticaria?

November 16, 2018

The change from baseline in 2-hour pruritus score was shown to be statistically noninferior from IV cetirizine to IV diphenhydramine, in favor of IV cetirizine.

Does Prearrival Epinephrine Adversely Affect Pediatric Anaphylaxis Patients?

November 16, 2018

Despite many pediatric patients receiving higher than recommended doses of epinephrine for their weight, they did not present with epinephrine-related symptoms.

Oralair Approved for Younger Patients With Grass Pollen Allergy

By November 14, 2018

Oralair is indicated as immunotherapy for the treatment of grass pollen-induced allergic rhinitis with or without conjunctivitis confirmed by positive skin test or in vitro testing for pollen specific IgE antibodies for any of the 5 grass species contained in this product.

Pharmacist-led educational intervention decreases inappropriate medications for older adults

November 13, 2018

Inappropriate prescribing of medications such as benzodiazepines, antihistamines, and anti-inflammatory drugs for older adults can lead to adverse events and hospitalization. Targeted educational efforts to deprescribe these medications have found to be successful.

Avocado Implicated in Several Food Protein-Induced Enterocolitis Syndrome Cases

By October 29, 2018

FPIES is a gastrointestinal food-associated hypersensitivity that often affects infants and toddlers and is marked by vomiting, diarrhea, fatigue, and pallor.

Expiration Dates Extended for Certain Lots of Generic Adrenaclick

By October 26, 2018

Epinephrine auto-injectors are indicated for the emergency treatment of allergic reactions (Type 1) including anaphylaxis.

BLA for Novel Peanut Allergy Treatment Submitted to FDA

By October 22, 2018

Viaskin Peanut, an epicutaneous immunotherapy (EPIT), delivers small amounts of peanut protein through a wearable patch to induce desensitization.

Dupilumab Studies Show Benefit in Chronic Rhinosinusitis With Nasal Polyps

By October 16, 2018

In both studies, at 24 weeks, patients treated with dupilumab plus corticosteroid nasal spray experienced a 51% and 57% improvement in nasal congestion/obstruction severity vs 15% and 19% improvement with nasal spray alone.

Omalizumab Improves Lung Function in Persistent Allergic Asthma

October 12, 2018

Patients with moderate to severe persistent allergic asthma who were treated with omalizumab experienced greater improvements in lung function after 16 weeks compared with those treated with placebo.

Xolair Prefilled Syringe Formulation Gets FDA Approval

By October 01, 2018

The PFS formulation eliminates the need to reconstitute the solution before administration.

Additional Symjepi Dosage Strength Approved for Anaphylaxis Treatment

By September 28, 2018

Both doses will be supplied in single-dose, prefilled syringes for manual injection.

Oral Allergy Treatments: Rx

September 26, 2018

A comparative dosing chart of prescription only oral medications for allergy treatment.

High-Risk Anticholinergics Prescribed to Six Percent of Elderly

September 25, 2018

The researchers found that a high-risk anticholinergic prescription was listed for 6.2% of visits of older adults between 2006 and 2015, representative of 14.6 million total visits nationally.

Addition of High-Dose Guaifenesin Benefits Patient With Chronic Respiratory Conditions

By September 13, 2018

According to the report, the patient complained of a non-productive cough, accumulation of mucus, and post-nasal drip and requested a thorough assessment of her medical conditions.

Veta Smart Case, App for Epinephrine Auto-Injectors Now Available

By September 06, 2018

The Smart Case includes electronics and sensors to monitor the proximity, temperature, presence and removal, and expiration of auto-injectors.

Walgreens to Offer Auvi-Q Nationwide in an Effort to Address Epinephrine Supply Issues

By September 06, 2018

This effort is in response to epinephrine auto-injector supply issues reported by manufacturers to the Food and Drug Administration (FDA).

Asthma Medicine Recalled Due to Tablet Mix-Up That May Pose Safety Risk

By August 31, 2018

The risk of a mixing-up the treatments is especially high for pregnant women, says the Food and Drug Administration (FDA), as losartan is indicated to treat high blood pressure and could harm or kill a fetus.

An Allergy to Red Meat May Be Tied to Heart Disease

August 31, 2018

The researchers found that 26% of patients had antibodies to α-Gal, indicating sensitivity to red meat. The sensitized patients had significantly higher levels of arterial plaque (30% higher) vs non-sensitized patients.

Novel Epinephrine Nasal Spray for Anaphylaxis Gets Fast Tracked by FDA

By August 31, 2018

The bioavailability of the novel epinephrine nasal spray also proved similar to that of intramuscular injection with EpiPen 0.3mg injection.

Many ED Visits for Antibiotic Adverse Drug Events in Children

August 31, 2018

Based on 6542 surveillance cases, the researchers estimated that 69,464 emergency department visits were made annually for antibiotic ADEs among children aged 19 years or younger from 2011 to 2015.

FDA Extends Expiration Date for Certain Lots of EpiPen

By August 21, 2018

This date modification beyond the approved 20-month shelf life was based an FDA review of product stability data submitted by Mylan.

First Generic Version of EpiPen Gets FDA Approval

By August 16, 2018

Unlike other generic approvals, epinephrine auto-injectors are considered "combination products" because they consist of both a drug and a device, making the approval process more challenging.