At study start, 21% of the more than 7,000 EMPA-REG OUTCOME trial participants had existing peripheral artery disease.
"Clinicians are seeing more heart failure with meth use, suggesting heart failure due to methamphetamine use could be a new epidemic," said lead author, Marin Nishimura, MD, in a statement.
This analysis indicates that on-treatment hsCRP testing may offer a quick and reliable way to identify the patients most likely to achieve the greatest benefits from long-term canakinumab treatment.
The combined endpoint evaluated was the time to event of atrial fibrillation, ventricular arrhythmia, heart failure, myectomy, ICD implant, or sudden cardiac arrest.
Data from the Duke University Health System (DUHS) electronic health records were used to identify patients with both diabetes and heart failure.
End-stage renal disease patients on dialysis with atrial fibrillation are at high risk for thrombotic complications.
The researchers used random forest machine-learning methods to identify risk factors associated with cardiovascular diseases based on data from the Framingham Heart Study.
A total of 5,177 patients at high risk for renal complications were randomized and scheduled for angiography to receive intravenous sodium bicarbonate or sodium chloride and 5 days of oral acetylcysteine or placebo.
The primary outcome of myocardial infarction or cardiac death at 30 days occurred in 12.4% of the 22,457 patients included in the meta-analysis.