Uveitis in Ankylosing Spondylitis: Risk Factors Identified
WASHINGTON, DC—Uveitis should be suspected in patients with ankylosing spondylitis (AS) who have high lesion counts, antistreptolysin O (ASO) and circulating immune complex (CIC) titers, according to retrospective research presented at the 2016 ACR/ARHP Annual Meeting.
“This study provides some evidence that hip-joint lesion, the number of peripheral arthritis, ASO and CIC may be associated with higher rates of uveitis in AS,” reported Feng Wang, MD, of the Nephrology and Rheumatology Department, Shanghai Jiao Tong University Affiliated Sixth People's Hospital in Shanghai, China. “The results of this comprehensive analysis suggest that the possible occurrence of uveitis in AS should not be neglected in patients who have those concomitant risk factors.”
The authors enrolled 390 patients with AS and ophthalmologist-diagnosed uveitis (80.5% male; mean age 33.3 years), between January and December 2015. Disease duration, HLA-B27, and peripheral hip-joint lesion counts were retrieved from medical records and imaging exams, and biochemical function labs were conducted.
Thirty-eight (9.7%) patients experienced at least one uveitis episode, and hip-joint lesions occurred at a higher incidence rate among these patients than those with no history of uveitis, the authors reported (44.7% vs. 22.2%; P<0.01). Patients in the uveitis-history study group also had higher peripheral arthritic lesion counts (2.18±0.23 vs. 0.55±0.04; OR, 4.1; 95%CI: 2.6-6.3; P<0.01), ASO (odds ratio [OR], 12.2; 95% CI:3.6-41.3; P<0.01), and CIC (P<0.0001).
“However, there were no significant differences in disease duration, HLA-B27, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) between the two groups,” the researchers found.