Increase seen in age-adjusted rate of drug overdose deaths involving xylazine from 0.03 to 1.06 per 100,000 standard population.
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Federal officials warn that the drug is increasingly being mixed with fentanyl
While not approved for human use, xylazine has been detected in combination with opioids (eg, illicit fentanyl), and with stimulants (eg, methamphetamine, cocaine).
Xylazine is centrally-acting alpha2-adrengeric agonist that was originally approved in 1972 as a sedative and analgesic for use in veterinary medicine.
More than 3000 people who died of an overdose in the US had xylazine in their system in 2021.