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Increase seen in age-adjusted rate of drug overdose deaths involving xylazine from 0.03 to 1.06 per 100,000 standard population.

Federal officials warn that the drug is increasingly being mixed with fentanyl

While not approved for human use, xylazine has been detected in combination with opioids (eg, illicit fentanyl), and with stimulants (eg, methamphetamine, cocaine).

Xylazine is centrally-acting alpha2-adrengeric agonist that was originally approved in 1972 as a sedative and analgesic for use in veterinary medicine.

More than 3000 people who died of an overdose in the US had xylazine in their system in 2021.

Kevzara approved for polymyalgia rheumatica; Skyclarys approved for Friedreich ataxia; Emergency authorization granted to at-home COVID-19, flu test; Drug-resistant bacteria virus spiking in the US; FDA clamps down on unlawful xylazine imports.

In 2019, xylazine contributed to death in 64 percent of cases and almost always also involved fentanyl