Proton pump inhibitor use is associated with shorter survival among patients with non-small cell lung cancer treated with pembrolizumab monotherapy.
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Is the use of proton pump inhibitors associated with empyema and lung abscess? Presenters at CHEST 2022 analyzed a large data base to address this question.
Is the use of proton pump inhibitors associated with empyema and lung abscess? Presenters at CHEST 2022 analyzed a large data base to address this question.
Findings showed that children who were initiated on PPIs were 57% more likely to be diagnosed with asthma.
Type 2 diabetes risk increased with increasing length of PPI use, particularly use for more than two years.
Small but significant risk seen for upper-limb and lower-limb fractures
The researchers found that a larger proportion of cases than controls had prior PPI use (70 vs 63%) or histamine-2 receptor antagonist use (25 vs 23%).
The case involved a 32-year-old male who was prescribed pantoprazole after initially presenting with dyspepsia-like symptoms.
The authors found that compared to the use of H2RA therapy, patients initiated on PPI therapy had a 25% increased risk of death (hazard ratio [HR] 1.25, 95% CI: 1.23-1.28).
The extent of risk also depended on the specific PPI taken.