Oral corticosteroid dosage reduction sustained in open-label extension study of dupilumab
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Patients with normal adrenal function are largely able to eliminate the use of oral corticosteroids or achieve a daily dose of 5 mg or less.
Drug-induced immunosuppression, particularly from oral corticosteroids, may limit response to COVID-19 vaccine
A post-hoc analysis of the VENTURE trial evaluated whether baseline oral corticosteroid dosage affected the efficacy of dupilumab in improving severe asthma outcomes.
Long-term treatment of oral corticosteroid (OCS)-dependent asthma with dupilumab has shown efficacy in weaning off OCS while improving lung function.
Zolgensma is an adeno-associated virus vector-based gene therapy.
Patients with flares more likely to have inpatient, emergency department visits
The FDA’s Fast Track process allows for expedited review of drugs that are expected to fill an unmet need.
Efzofitimod is a potential first-in-class selective modulator of neuropilin-2 that is designed to downregulate innate and adaptive immune responses in inflammatory disease states.
The BLA submission is supported by data from the PATHFINDER clinical program.