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BRAF V600 Targetable in Some Nonmelanoma Cancers

For some, but not all, nonmelanoma cancers, BRAF V600 is a targetable oncogene, with activity seen in non-small-cell lung cancer and Erdheim-Chester disease and Langerhans'-cell histiocytosis.
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AACR: Lengthy Survival in Some Receiving NSCLC Vaccine

Use of belagenpumatucel-L, a therapeutic vaccine comprised of four tumor growth factor-β2 antisense gene-modified allogeneic non-small-cell lung cancer (NSCLC) cell lines, is associated with encouraging long-term survival for patients with Stage IIIB and IV NSCLC.
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Erlotinib Plus Chemo Doesn’t Improve Efficacy in NSCLC

Adding chemotherapy with carboplatin plus paclitaxel to the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib does not improve efficacy in the treatment of chemotherapy-naive, never or light former smokers with advanced non-small-cell lung cancer (NSCLC).
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Immune Checkpoint Inhibitor Efficacy Varies by Sex

The researchers found that, compared with men treated in control groups, the pooled overall survival hazard ratio was 0.72 for male patients treated with immune checkpoint inhibitors.
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AACR: IL-2, 13-Cis Retinoic Acid Beneficial in Advanced Cancer

For patients with advanced cancer, a combination of low-dose interleukin-2 (IL-2) and 13-cis retinoic acid (RA) increases natural killer (NK) cells, decreases expression of vascular endothelial growth factor (VEGF), and improves overall survival (OS).