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Diovan Approved for Younger Patients With Hypertension
The approval was based on data from 3 clinical studies that assessed the antihypertensive effect of valsartan in 290 children 1 to less than 6 years of age.
Within two to four months, increases, decreases in systolic BP seen in transmasculine, transfeminine adults, respectively
Significant reduction found in risk for disease progression/death for C+R versus placebo and rituximab
Increased exposure linked to significantly increased rates of incident keratinocyte carcinoma, melanoma in adults ≥66 years
However, authors warn that stagnation and possible increase in more recent years may indicate reversal of trend
Twenty-five percent experienced CVD event during follow-up; risk up for ß-blocker use but not with calcium channel blockers, diuretics