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Combination Therapy for Treatment-Resistant Depression: Should MAOIs Be Included?

Because some research has indicated benefits of MAOIs combined with another antidepressant for treatment-resistant depression (TRD), a review in Pharmacotherapy evaluated data from published studies and case reports and the medical records of 29 adult patients from a large Midwestern teaching hospital on the safety and efficacy of combination therapy with MAOIs and other antidepressants or stimulants for TRD.
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HCTZ vs. Indapamide and Chlorthalidone: Head-to-Head Trials Reviewed

Thiazide-related diuretics are recommended as first-line treatment in most hypertension guidelines and have been shown to be especially beneficial in resistant and salt-sensitive forms of hypertension. However, there are variations in the properties of thiazide-related medications and few studies have compared hydrochlorothiazide (HCTZ) with the thiazide-like indapamide (INDAP) and chlorthalidone (CTDN) despite the fact that both INDAP and CTDN have been recommended as a replacement for HCTZ.
Drug News

First-Line Treatment for Hypertension: Comparing Classes

Renin-angiotensin system (RAS) inhibitors including angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are widely prescribed to patients, but how does their safety and efficacy compare to other antihypertensive drug classes?
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Tablet Splitting: When Is It OK?

Tablet splitting may not always result in weight-uniform half tablets which may result in inaccurate dosing.
Drug News

Cardiac Benefits Seen with Pharmacologic Tx for Mild Hypertension

Blood pressure-lowering pharmacologic therapy may have significant effects on reduction of cardiovascular events in patients with grade 1 hypertension (140-159/90-99mmHg), particularly for those with an elevated absolute cardiovascular risk.
Drug News

Meditation as Medicine: Reviewing TM for CVD Prevention

Evidence suggests that psychosocial stress may be an independent risk factor for cardiovascular disease (CVD) in patients with and without CVD, but research on transcendental meditation (TM) to reduce this modifiable risk factor is limited.
Drug News

Sugar vs. Salt: Which is Worse for the Heart?

Research on the potential benefits of sodium reduction for treatment of hypertension has yielded conflicting results, with some evidence suggesting that reducing sodium intake could actually increase cardiovascular and all-cause mortality in patients with diabetes.