Fluconazole 2mg/mL; soln for IV infusion.
Fluconazole 50mg, 100mg, 200mg; tabs.
Fluconazole 10mg/mL, 40mg/mL; pwd for oral susp; orange flavor; contains sucrose.
Based on the findings, it was concluded that fluconazole use during pregnancy was not associated with significantly increased risks of stillbirth or neonatal death. However, the authors cautioned that the confidence intervals were wide and neither result was statistically significant.
Any exposure increases spontaneous abortion risk; cardiac septal defects up for use in early pregnancy
The FDA is informing the public that chronic therapy with high-doses of Diflucan (fluconazole; Pfizer) may be associated with a rare and distinct set of birth defects in infants whose mothers were treated in the first trimester of pregnancy.
Low doses of fluconazole during pregnancy do not increase the risk of most birth defects but may confer an increased risk of tetralogy of Fallot.
IDWeek 2012: Pediatric Infectious Diseases
David A. Kaufman, MD, from the University of Virginia, presented study findings at IDWeek 2012 that showed targeted prophylaxis of fluconazole in infants <1,000g or ≤27 weeks using a 3mg/kg twice-weekly dose with a different antifungal used for treatment is effective in preventing invasive Candida infections.
Using the oral antifungal medication fluconazole during pregnancy has been associated with an increased risk of spontaneous abortion.