Latest findings are from a post hoc meta-analysis of pooled data from the DAPA-HF and DELIVER trials.
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Guidelines support the use of RAASi at the maximum tolerated dose in patients with CKD and heart failure.
Despite a warning from the FDA Adverse Event Reporting System, studies have found that SGLT2 inhibitor use is not associated with an increased risk of AKI.
Up to 40% of patients with IgAN progress to end-stage kidney disease, investigators noted.
Patients receiving significant amount of immunosuppression prior to kidney transplantation should be counseled on these malignancy risks, according to investigators.
If renin-angiotensin system inhibitors are indicated in patients with advanced CKD, they should not be stopped just because of low eGFR, investigators concluded.
Daprodustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor.
Danish investigators compared direct oral anticoagulants with vitamin K antagonists in 33,670 patients with atrial fibrillation.
Patients with advanced CKD have not been well-represented in trials evaluating intensive blood pressure control.
Tecarfarin is a novel oral vitamin K antagonist with a similar mechanism of action to warfarin, though it is metabolized differently.