Allopurinol 100mg, 300mg; scored tabs.
Allopurinol (as sodium) 500mg/vial; pwd for IV infusion after reconstitution and dilution; preservative-free.
American College of Cardiology 2013
Allopurinol reduced the incidence of atrial fibrillation (AF) in patients with heart failure, a retrospective cohort study presented at ACC.13, the American College of Cardiology's 62nd Annual Scientific Session, has found.
Drugs in the Pipeline
AstraZeneca announced top-line results for two pivotal Phase 3 trials investigating lesinurad, when used in combination with xanthine oxidare (XO) inhibitor allopurinol in patients with symptomatic gout not achieving target sUA levels on current allopurinol dose.
Allopurinol initiators have an almost 10-fold increased risk of severe cutaneous adverse reactions (SCARs) compared with nonusers.
Compared with non-users, allopurinol use ≥300mg/day was correlated with a lower risk for developing chronic kidney disease stage ≥3.
Allopurinol and febuxostat were found to be associated with a higher risk of hypersensitivity reactions when compared to colchicine, according to the results of a recently published population-based study.
This fixed-dose combination product combines lesinurad, a uric acid transporter 1 (URAT1) inhibitor, with allopurinol, a xanthine oxidase inhibitor in one tablet.
Participants were followed for a median of 32 months.
Adding lesinurad to allopurinol provided extra benefit vs. allopurinol alone in lower serum urate (sUA) levels and is an option for patients requiring additional urate-lowering, a study published in Arthritis & Rheumatology reported.