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FDA Approves OTC Combination of Ibuprofen and Acetaminophen

The FDA has approved Advil Dual Action with Acetaminophen (GlaxoSmithKline), the first over-the-counter (OTC) fixed-dose combination therapy containing ibuprofen and acetaminophen for the temporary relief of minor aches and pains due to headache, backache, muscular aches, toothache, menstrual cramps, and minor pain of arthritis. Each caplet contains 125mg of Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID)…
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Acetaminophen Can Reduce Recurrence of Febrile Seizures

Rectal acetaminophen use was the largest contributor to the prevention of FS recurrence during the same fever episode among the variables in the final multiple logistic regression analysis (odds ratio, 5.6; 95% confidence interval, 2.3 to 13.3).
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IV Acetaminophen Minimally Helpful for Colectomy Pain

More than 1 dose of intravenous acetaminophen on postoperative day 1 was associated with lower opioid utilization (−12.4%) vs non-use, while an even stronger reduction was seen in those receiving more than one oral acetaminophen dose (−22.6%).
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Acetaminophen Use During Pregnancy Linked to Offspring ADHD

Results showed that after adjusting for maternal use of acetaminophen pre-pregnancy, familial risk and indications of acetaminophen use, the hazard ratio (HR) of ADHD with ≥29 days of acetaminophen use was 2.20 (95% CI; 1.50-3.24).