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Findings may help with decision-making in this high-risk patient population.
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Although more research is needed, data suggest that the cardioprotective effect of direct oral anticoagulants may extend to patients with advanced CKD.
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The patients, a 71-year-old male and a 62 year-old-male, both on long-term warfarin therapy, presented to the emergency department with symptoms of COVID-19.
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No differences seen in fracture risk in head-to-head comparisons of direct oral anticoagulants
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Morning or evening administration makes no difference on time outside target INR range.
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Noninferiority not found compared with standard-intensity prophylaxis with hip or knee arthroplasty
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Findings seen in warfarin-treated patients with history of international normalized ratio instability
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Compared with warfarin, apixaban was correlated with reduced risk of major bleeding and intracranial bleeding (adjusted hazard ratios, 0.66 and 0.4, respectively) and dabigatran was correlated with reduced risk of intracranial bleeding (adjusted hazard ratio, 0.45) among patients with atrial fibrillation.
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Similar number of out-of-range next INR values for patients with, without extended testing interval
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"Repackaging of warfarin sodium tablets into DAAs does not affect the chemical stability," the authors wrote.