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Vadadustat Noninferior to Darbepoetin in CKD

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Despite favorable efficacy data, the HIF-PHI failed to demonstrate noninferiority to the ESA in patients with CKD with respect to the primary MACE safety endpoint.
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Aggressive Control of BP, Lipids in T2DM May Up Kidney Risk

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"We believe that the data actually suggest possible benefit for ESKD [end-stage kidney disease] with intensive glucose control, and remain inconclusive for intensive blood pressure control and fibrate use given the wide confidence intervals for the more reliable ESKD outcomes," write the authors.