Researchers find oxygen therapy does not improve quality of life, forestall hospitalization, lengthen lives
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Findings showed that the trial did not meet statistical significance on the primary endpoint.
Authors call for larger clinical trials to further evaluate the efficacy and safety of colchicine as an adjunctive therapy for COVID-19
The EUA was granted based on data from the phase 3 ACTT-2 trial, which was conducted by the NIAID.
The study, which was fully remote and contactless, aimed to evaluate whether early treatment with fluvoxamine reduced the likelihood of clinical deterioration and disease severity in patients with mild COVID-19 illness.
Lenzilumab is an investigational anti-human granulocyte macrophage-colony stimulating factor monoclonal antibody.
The FDA approved Veklury (remdesivir; Gilead Sciences) for the treatment of COVID-19 in patients aged ≥12 years (weighing ≥40kg) requiring hospitalization.
Intubation or death, disease worsening similar for tocilizumab, placebo in hospitalized patients.
Both randomized, placebo-controlled trials are expected to enroll approximately 1000 hospitalized patients.
The ACTT-2 study began on May 8 and included more than 1000 patients.