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Elacestrant showed a statistically significant and clinically meaningful progression-free survival improvement compared with standard of care.

Camizestrant improved progression-free survival vs fulvestrant in postmenopausal patients with ER+, HER2- advanced breast cancer.

Monitoring bESR1mut enabled optimization of the endocrine therapy used with a CDK4/6 inhibitor.

The duration of prior treatment with a CDK4/6 inhibitor appears to impact progression-free survival with elacestrant in ER+/HER2- metastatic breast cancer.